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Does Ceftin (cefuroxime) cause side effects?
Ceftin (cefuroxime) is a cephalosporin antibiotic used to treat infections of the middle ear, sinuses, skin, tonsils, and throat, and to treat laryngitis, bronchitis, pneumonia, urinary tract infections, gonorrhea, COPD, and early Lyme disease.
Cephalosporins stop or slow the growth of bacterial cells by preventing bacteria from forming the cell wall that surrounds each cell. The cell wall protects bacteria from the external environment and keeps the contents of the cell together. Without a cell wall, bacteria are not able to survive.
Common side effects of Ceftin include
Serious side effects of Ceftin include
- allergic reactions (sometimes even anaphylaxis),
- severe skin reactions,
- seizures, and
- Clostridium difficile-associated diarrhea, which may range in severity from mild diarrhea to fatal pseudomembranous colitis.
Drug interactions of Ceftin include probenecid, which increases the concentration of Ceftin in the blood. Drugs that reduce acidity in the stomach (for example, antacids, H2-blockers, proton pump inhibitors) may reduce absorption of Ceftin.
Cephalosporins including Ceftin are usually considered safe for use during pregnancy.
What are the important side effects of Ceftin (cefuroxime)?
Cefuroxime is generally well tolerated, and side effects are usually transient. Commonly reported side effects are:
Other important side effects include:
Since cefuroxime is chemically related to penicillin, patients allergic to penicillin may develop an allergic reaction (sometimes even anaphylaxis) to cefuroxime. Cefuroxime like other antibiotics can alter the colon's normal bacteria, leading to overgrowth of a bacterium called Clostridium difficile.
Overgrowth of this bacterium leads to the release of toxins that contribute to the development of Clostridium difficile-associated diarrhea, which may range in severity from mild diarrhea to fatal pseudomembranous colitis.
Ceftin (cefuroxime) side effects list for healthcare professionals
The following serious and otherwise important adverse reaction is described in greater detail in the Warnings and Precautions section of the label:
Anaphylactic Reactions (see prescribing information).
Clinical Trials Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice.
Multiple-Dose Dosing Regimens With 7 To 10 Days’ Duration
In multiple-dose clinical trials, 912 subjects were treated with Ceftin (125 to 500 mg twice daily). It is noted that 125 mg twice daily is not an approved dosage. Twenty (2.2%) subjects discontinued medication due to adverse reactions.
Seventeen (85%) of the 20 subjects who discontinued therapy did so because of gastrointestinal disturbances, including
- vomiting, and
- abdominal pain.
The percentage of subjects treated with Ceftin who discontinued study drug because of adverse reactions was similar at daily doses of 1,000, 500, and 250 mg (2.3%, 2.1%, and 2.2%, respectively). However, the incidence of gastrointestinal adverse reactions increased with the higher recommended doses.
The adverse reactions in Table 5 are for subjects (n = 912) treated with Ceftin in multiple-dose clinical trials.
Table 5: Adverse Reactions (≥1%) after
Multiple-Dose Regimens with Ceftin Tablets
(n = 912)
|Blood and lymphatic system disorders|
|Transient elevation in AST||2%|
|Transient elevation in ALT||2%|
|Transient elevation in LDH||1%|
The following adverse reactions occurred in less than 1% but greater than 0.1% of subjects (n = 912) treated with Ceftin in multiple-dose clinical trials.
- Immune System Disorders: Hives, swollen tongue.
- Metabolism and Nutrition Disorders: Anorexia.
- Nervous System Disorders: Headache.
- Cardiac Disorders: Chest pain.
- Respiratory Disorders: Shortness of breath.
- Gastrointestinal Disorders: Abdominal pain, abdominal cramps, flatulence, indigestion, mouth ulcers.
- Skin and Subcutaneous Tissue Disorders: Rash, itch.
- Renal and Urinary Disorders: Dysuria.
- Reproductive System and Breast Disorders: Vaginitis, vulvar itch.
- General Disorders and Administration Site Conditions: Chills, sleepiness, thirst.
- Investigations: Positive Coombs' test.
Early Lyme Disease With 20-Day Regimen
Two multicenter trials assessed Ceftin 500 mg twice daily for 20 days. The most common drug-related adverse experiences were diarrhea (10.6%), Jarisch-Herxheimer reaction (5.6%), and vaginitis (5.4%). Other adverse experiences occurred with frequencies comparable to those reported with 7 to 10 days' dosing.
Single-Dose Regimen For Uncomplicated Gonorrhea
In clinical trials using a single 1,000-mg dose of Ceftin, 1,061 subjects were treated for uncomplicated gonorrhea. The adverse reactions in Table 6 were for subjects treated with a single dose of 1,000 mg Ceftin in U.S. clinical trials.
Table 6: Adverse Reactions (≥1%) after Single-Dose
Regimen with 1,000-mg Ceftin Tablets
for Uncomplicated Gonorrhea
(n = 1,061)
The following adverse reactions occurred in less than 1% but greater than 0.1% of subjects (n = 1,061) treated with a single dose of Ceftin 1,000 mg for uncomplicated gonorrhea in U.S. clinical trials.
- Infections and Infestations: Vaginal candidiasis.
- Nervous System Disorders: Headache, dizziness, somnolence.
- Cardiac Disorders: Tightness/pain in chest, tachycardia.
- Gastrointestinal Disorders: Abdominal pain, dyspepsia.
- Skin and Subcutaneous Tissue Disorders: Erythema, rash, pruritus.
- Musculoskeletal and Connective Tissue Disorders: Muscle cramps, muscle stiffness, muscle spasm of neck, lockjaw-type reaction.
- Renal and Urinary Disorders: Bleeding/pain in urethra, kidney pain.
- Reproductive System and Breast Disorders: Vaginal itch, vaginal discharge.
In clinical trials using multiple doses of Ceftin, pediatric subjects (96.7% were younger than 12 years) were treated with Ceftin (20 to 30 mg/kg/day divided twice daily up to a maximum dose of 500 or 1,000 mg/day, respectively). Eleven (1.2%) U.S. subjects discontinued medication due to adverse reactions.
The discontinuations were primarily for gastrointestinal disturbances, usually diarrhea or vomiting. Thirteen (1.4%) U.S. pediatric subjects discontinued therapy due to the taste and/or problems with drug administration.
The adverse reactions in Table 7 are for U.S. subjects (n = 931) treated with Ceftin in multiple-dose clinical trials.
Table 7: Adverse Reactions (>1%) after
Multiple-Dose Regimens with Ceftin for Oral Suspension
(n = 931)
|Dislike of taste||5%|
|Skin and subcutaneous tissue disorders|
The following adverse reactions occurred in less than 1% but greater than 0.1% of U.S. subjects (n = 931) treated with Ceftin for oral suspension in multiple-dose clinical trials.
- Infections and Infestations: Gastrointestinal infection, candidiasis, viral illness, upper respiratory infection, sinusitis, urinary tract infection.
- Blood and Lymphatic System Disorders: Eosinophilia.
- Psychiatric Disorders: Hyperactivity, irritable behavior.
- Gastrointestinal Disorders: Abdominal pain, flatulence, ptyalism.
- Skin and Subcutaneous Tissue Disorders: Rash.
- Musculoskeletal and Connective Tissue Disorders: Joint swelling, arthralgia.
- Reproductive System and Breast Disorders: Vaginal irritation.
- General Disorders and Administration Site Conditions: Cough, fever.
- Investigations: Elevated liver enzymes, positive Coombs' test.
The following adverse reactions have been identified during post-approval use of Ceftin. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Blood and Lymphatic System Disorders
Immune System Disorders
- Increased prothrombin time.
Nervous System Disorders
Renal and Urinary Disorders
- Renal dysfunction.
Skin and Subcutaneous Tissue Disorders
What drugs interact with Ceftin (cefuroxime)?
- Cefuroxime axetil may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.
- Counsel patients to consider alternate supplementary (non-hormonal) contraceptive measures during treatment.
Drugs That Reduce Gastric Acidity
- Drugs that reduce gastric acidity may result in a lower bioavailability of Ceftin compared with administration in the fasting state.
- Administration of drugs that reduce gastric acidity may negate the food effect of increased absorption of Ceftin when administered in the postprandial state.
- Administer Ceftin at least 1 hour before or 2 hours after administration of short-acting antacids. Histamine-2 (H2) antagonists and proton pump inhibitors should be avoided.
- Concomitant administration of probenecid with cefuroxime axetil tablets increases serum concentrations of cefuroxime.
- Coadministration of probenecid with cefuroxime axetil is not recommended.
Drug/Laboratory Test Interactions
- A false-positive reaction for glucose in the urine may occur with copper reduction tests (e.g., Benedict's or Fehling's solution), but not with enzyme-based tests for glycosuria.
- As a false-negative result may occur in the ferricyanide test, it is recommended that either the glucose oxidase or hexokinase method be used to determine blood/plasma glucose levels in patients receiving cefuroxime axetil.
- The presence of cefuroxime does not interfere with the assay of serum and urine creatinine by the alkaline picrate method.
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Related Disease Conditions
What are the Four Stages of COPD?
COPD (chronic obstructive pulmonary disease) is a group of diseases that cause an inflammatory reaction and irreversible damage in the lungs. The result is obstruction of normal airflow and breathing difficulties. COPD is a lifelong condition with periods of flare ups, and is not curable in any stage of the disease. Emphysema and chronic bronchitis are the most common diseases that make up COPD.
Pneumonia is inflammation of the lungs caused by fungi, bacteria, or viruses. Symptoms and signs include cough, fever, shortness of breath, and chills. Antibiotics treat pneumonia, and the choice of the antibiotic depends upon the cause of the infection.
Is Pneumonia Contagious?
Pneumonia is inflammation of the lung usually caused by bacterial or viral infection (rarely, also by fungi) that causes the air sacs to fill with pus. If inflammation affects both lungs, the infection is termed double pneumonia. If it affects one lung, it is termed single pneumonia. If it affects only a certain lobe of a lung it's termed lobar pneumonia. Most pneumonias are caused by bacteria and viruses, but some pneumonias are caused by inhaling toxic chemicals that damage lung tissue.
Bronchitis is inflammation of the airways in the lung. Acute bronchitis is short in duration (10-20 days) in comparison with chronic bronchitis, which lasts for months to years. Causes of acute bronchitis include viruses and bacteria, which means it can be contagious. Acute bronchitis caused by environmental factors such as pollution or cigarette smoke is not contagious. Common symptoms for acute bronchitis include nasal congestion, cough, headache, sore throat, muscle aches, and fatigue. Acute bronchitis in children also my include runny nose, fever, and chest pain. Treatment for acute bronchitis are OTC pain relievers, cough suppressants (although not recommended in children), and rest. Infrequently antibiotics may be prescribed to treat acute bronchitis.
COPD vs. Emphysema
COPD (chronic obstructive pulmonary disease) is the term doctors and other healthcare professionals use to describe a group of serious, progressive (worsens over time), chronic lung diseases that include emphysema, chronic bronchitis, and sometimes asthma. The number one cause of COPD or emphysema, is smoking, and smoking is the third leading cause of death in the US.
COPD (Chronic Obstructive Pulmonary Disease)
COPD or chronic obstructive pulmonary disease is a lung condition caused by smoking tobacco, exposure to secondhand smoke, and/or air pollutants. Conditions that accompany COPD include chronic bronchitis, chronic cough, and emphysema. Symptoms of COPD include shortness of breath, wheezing, and chronic cough. Treatment of COPD includes GOLD guidelines, smoking cessation, medications, and surgery. The life expectancy of a person with COPD depends on the stage of the disease.
COPD vs. Asthma (Differences and Similarities)
COPD (chronic obstructive pulmonary disease) and asthma both have common symptoms like coughing, wheezing, shortness of breath, and a tight feeling in the chest. COPD is caused by tobacco smoking, while asthma is caused by your inherited genetic makeup and their interactions with the environment. Risk factors for asthma are obesity, exposure to cigarette smoke (even secondhand smoke), and personal history of hay fever. There is no cure for either disease, but symptoms can be managed with medication. A person with asthma has a better prognosis and life expectancy than someone with COPD.
Chronic bronchitis is a cough that occurs daily with production of sputum that lasts for at least 3 months, 2 years in a row. Causes of chronic bronchitis include cigarette smoking, inhaled irritants, and underlying disease processes (such as asthma, or congestive heart failure). Symptoms include cough, shortness of breath, and wheezing. Treatments include bronchodilators and steroids. Complications of chronic bronchitis include COPD and emphysema.
How Long Is Pneumonia Contagious?
Pneumonia may be contagious for 2-14 days. Usually, the goal of medications given for pneumonia is to limit the spread of the disease.
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Interstitial Lung Disease (Interstitial Pneumonia)
Interstitial lung disease refers to a variety of diseased that thicken the tissue between the lungs' air sacks. Symptoms of interstitial lung disease include shortness of breath, cough, and vascular problems, and their treatment depends on the underlying cause of the tissue thickening. Causes include viruses, bacteria, tobacco smoke, environmental factors, cancer, and heart or kidney failure.
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Pneumonia is a lung infection that affects many people. Learn the signs of pneumonia, what causes it, how doctors diagnose it, and what you can do to treat it.
Can Pneumonia Go Away On Its Own?
Mild pneumonia may be healed by body’s defense system. However severe cases of pneumonia require medical attention especially viral pneumonia.
What Is the Treatment for Asthmatic Bronchitis?
Asthmatic bronchitis refers to inflammation of the bronchial tubes carrying air inside the lungs that occurs because of asthma. Treatment for asthmatic bronchitis involves bronchodilators, steroids, treating secretions, leukotriene inhibitors, antibiotics, oxygen administration and avoiding triggers.
How Long Does Asthmatic Bronchitis Last?
The duration of the disease usually depends on the patient’s overall health and age. In patients with acute bronchitis symptoms may last less than 10 days. In patients with severe asthmatic bronchitis, the symptoms are recurrent and usually last between 30 days to even 2 years with flares and remissions.
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What to Do When a Cold Becomes Bronchitis?
Bronchitis or “chest cold” refers to the inflammation of the airways (bronchial tubes) in the lungs. Air passes through the lungs within a network of tubules called bronchial tubes. Bronchitis is often associated with persistent, nagging coughs with mucus.
Viral pneumonia: Symptoms, Causes And Treatment
Pneumonia is an infection in your lungs that is usually caused by bacteria, viruses or fungi. About 30% of pneumonia cases reported in the United States are viral. Symptoms include dry cough, fever, chills, difficulty breathing, chest pain and rapid breathing.
How Do You Get Rid of Bronchitis Naturally?
Bronchitis is swelling of airways mostly due to a virus. Rarely, bacteria or fungi can also be the reason. Swelling in bronchial tubes may restrict air to and from your lungs. It typically causes a bad cough, chest discomfort, and fatigue. You may need to consult a doctor to distinguish bronchitis from pneumonia.
Can People With COPD Get Better?
Chronic obstructive pulmonary disease (COPD) is not curable in any stage of the disease. With early diagnosis and treatment, disease progression and flare-ups can be controlled.
What Are the Main Causes of Bronchitis?
Bronchitis is an inflammation of the tubes that carry air to and from your lungs. Learn the signs of bronchitis, what causes bronchitis, how doctors diagnose bronchitis, and what you can do to treat bronchitis.
Emphysema, Chronic Bronchitis, and Colds
If you have a COPD such as emphysema, avoiding chronic bronchitis and colds is important to avoid a more severe respiratory infection such as pneumonia. Avoiding cigarette smoking, practice good hygeine, stay away from crowds, and alerting your healthcare provider if you have a sinus infection or cold or cough that becomes worse. Treatment options depend upon the severity of the emphysema, bronchitis, or cold combination.
How Do You Know if Your Baby has Bronchitis?
Acute bronchitis, which is sometimes called a chest cold, can develop after your baby has a cold or upper respiratory infection. Bronchitis occurs when the bronchi, the airways that carry air to the lungs, become irritated and inflamed.
How Do I Know if My Child has Pneumonia?
Pneumonia is a lung infection that affects many children. Learn the signs of pneumonia in children, what causes pneumonia in children, how doctors diagnose pneumonia in children, and what you can do to treat pneumonia in children.
What Helps When You Have Bronchitis?
Bronchitis refers to the inflammation of the air-carrying tubes in the lungs (bronchioles). The condition is often associated with persistent, nagging cough with mucus. The condition often starts as an infection of the nose, throat, ears, or sinuses that later moves to the bronchi.
Treatment & Diagnosis
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Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.