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Does Raniclor (cefaclor) cause side effects?
Like other cephalosporins, cefaclor stops bacteria from multiplying by preventing bacteria from forming the walls that surround them. The walls are necessary to protect bacteria from their environment and to keep the contents of the bacterial cell together. Bacteria cannot survive without a cell wall.
Common side effects of cefaclor include
- joint pain,
- abnormal liver tests,
- yellowing skin and eyes (jaundice),
- insomnia, and
Drug interactions of cefaclor include aluminum or magnesium-containing antacids, which reduce the absorption of cefaclor from the intestine. Separating the administration of cefaclor and such antacids by one hour prevents this interaction.
There are no adequate studies of cefaclor in pregnant women.
What are the important side effects of Raniclor (cefaclor)?
Cefaclor is generally well tolerated, and side effects usually are transient. Reported side effects include:
- joint pain,
- abnormal liver tests,
- insomnia, and
Cefaclor should be avoided by patients with known allergy to cephalosporin type antibiotics. Since cefaclor is chemically related to penicillin, patients allergic to penicillin can have an allergic reaction (sometimes even anaphylaxis) if given cefaclor.
Treatment with cefaclor and other antibiotics can alter the normal bacteria flora of the colon and permit overgrowth of C. difficile, a bacteria responsible for pseudomembranous colitis. Patients who develop pseudomembranous colitis as a result of antibiotics treatment can experience diarrhea, abdominal pain, fever, and sometimes even shock.
Raniclor (cefaclor) side effects list for healthcare professionals
Adverse effects considered to be related to therapy with cefaclor are listed below:
- Hypersensitivity reactions have been reported in about 1.5% of patients and include morbilliform eruptions (1 in 100). Pruritus, urticaria, and positive Coombs' tests each occur in less than 1 in 200 patients.
- Cases of serum-sickness-like reactions have been reported with the use of cefaclor. These are characterized by findings of erythema multiforme, rashes, and other skin manifestations accompanied by arthritis/arthralgia, with or without fever, and differ from classic serum sickness in that there is infrequently associated lymphadenopathy and proteinuria, no circulating immune complexes, and no evidence to date of sequelae of the reaction.
- Occasionally, solitary symptoms may occur, but do not represent a serum-sickness-like reaction. While further investigation is ongoing, serum-sickness-like reactions appear to be due to hypersensitivity and more often occur during or following a second (or subsequent) course of therapy with cefaclor.
- Such reactions have been reported more frequently in pediatric patients than in adults with an overall occurrence ranging from 1 in 200 (0.5%) in one focused trial to 2 in 8,346 (0.024%) in overall clinical trials (with an incidence in pediatric patients in clinical trials of 0.055%) to 1 in 38,000 (0.003%) in spontaneous event reports.
- Signs and symptoms usually occur a few days after initiation of therapy and subside within a few days after cessation of therapy; occasionally these reactions have resulted in hospitalization, usually of short duration (median hospitalization = 2 to 3 days, based on postmarketing surveillance studies).
- In those requiring hospitalization, the symptoms have ranged from mild to severe at the time of admission with more of the severe reactions occurring in pediatric patients.
- Antihistamines and glucocorticoids appear to enhance resolution of the signs and symptoms. No serious sequelae have been reported.
- More severe hypersensitivity reactions, including
- Anaphylactoid events may be manifested by solitary symptoms, including
- Anaphylaxis may be more common in patients with a history of penicillin allergy.
- Rarely, hypersensitivity symptoms may persist for several months.
- Gastrointestinal symptoms occur in about 2.5% of patients and include diarrhea (1 in 70).
- Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment. Nausea and vomiting have been reported rarely. As with some penicillins and some other cephalosporins, transient hepatitis and cholestatic jaundice h have been reported rarely.
- Other effects considered related to therapy included
Causal Relationship Uncertain
- CNS—Rarely, reversible hyperactivity, agitation, nervousness, insomnia, confusion, hypertonia, dizziness, hallucinations, and somnolence have been reported.
- Transitory abnormalities in clinical laboratory test results have been reported. Although they were of uncertain etiology, they are listed below to serve as alerting information for the physician.
- Hepatic—Slight elevations of AST, ALT, or alkaline phosphatase values (1 in 40).
- Hematopoietic—As has also been reported with other β-lactam antibiotics, transient lymphocytosis, leukopenia, and, rarely, hemolytic anemia, aplastic anemia, agranulocytosis, and reversible neutropenia of possible clinical significance.
- There have been rare reports of increased prothrombin time with or without clinical bleeding in patients receiving cefaclor and Coumadin® concomitantly.
- Renal—Slight elevations in BUN or serum creatinine (less than 1 in 500) or abnormal urinalysis (less than 1 in 200).
Cephalosporin-class Adverse Reactions
In addition to the adverse reactions listed above that have been observed in patients treated with cefaclor, the following adverse reactions and altered laboratory tests have been reported for cephalosporin-class antibiotics:
- abdominal pain,
- renal dysfunction,
- toxic nephropathy,
- false-positive test for urinary glucose,
- elevated bilirubin,
- elevated LDH, and
Several cephalosporins have been implicated in triggering seizures, particularly in patients with renal impairment when the dosage was not reduced. If seizures associated with drug therapy occur, the drug should be discontinued. Anticonvulsant therapy can be given if clinically indicated.
To report SUSPECTED ADVERSE REACTIONS, contact FSC Laboratories, Inc. at 1-866-764-7822 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
What drugs interact with Raniclor (cefaclor)?
Drug/Laboratory Test Interactions
- Patients receiving cefaclor may show a false-positive reaction for glucose in the urine with tests that use Benedict's and Fehling's solutions and also with Clinitest tablets.
- There have been reports of increased anticoagulant effect when cefaclor and oral anticoagulants were administered concomitantly.
Raniclor (cefaclor) is a semi-synthetic cephalosporin antibiotic prescribed for staph, E. coli, middle ear, and urinary tract infections (UTIs), and for tonsilitis, bronchitis, and laryngitis. Common side effects of cefaclor include rash, fever, joint pain, arthritis, abnormal liver tests, yellowing skin and eyes (jaundice), vaginitis, itching, nervousness, insomnia, and hallucinations. There are no adequate studies of cefaclor in pregnant women. Small amounts of cefaclor are secreted in breast milk.
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Related Disease Conditions
Laryngitis is an inflammation of the voice box (vocal cords). The most common cause of acute laryngitis is an infection, which inflames the vocal cords. Symptoms may vary from the degree of laryngitis and age of the person (laryngitis in infants and children is more commonly caused by croup).
Inner Ear Infection
An inner ear infection or otitis interna is caused by viruses or bacteria and can occur in both adults and children. An inner ear infection can cause symptoms and signs, for example, a severe ear, dizziness, vertigo, nausea and vomiting, and vertigo. An inner ear infection also may cause inflammation of the inner ear or labyrinthitis. Inner ear infections are not contagious; however, the bacteria and viruses that cause the infection can be transmitted to other people. Good hygiene practices will help decrease the chances of the infection spreading to others. Inner ear infection symptoms and signs like ear pain and nausea may be relieved with home remedies or over-the-counter (OTC) medication. Some inner ear infections will need to be treated and cured with antibiotics or prescription pain or antinausea medication.
Urinary Tract Infection (UTI)
A urinary tract infection (UTI) is an infection of the bladder, kidneys, ureters, or urethra. E. coli, a type of bacteria that lives in the bowel and near the anus, causes most UTIs. UTI symptoms include pain, abdominal pain, mild fever, urinary urgency, and frequency. Treatment involves a course of antibiotics.
Inner Ear Infection (Labyrinthitis)
Labyrinthitis occurs when there is inflammation of the part of the ear responsible for balance and hearing), usually due to viral infections of the inner ear. Learn about causes, symptoms, and treatment.
Middle Ear Infection (Otitis Media)
A middle ear infection (otitis media) can cause earache, temporary hearing loss, and pus drainage from the ear. It is most common in babies, toddlers, and young children. Learn about causes and treatment.
Ear Infection Home Treatment
Infections of the outer, middle, and inner ear usually are caused by viruses. Most outer (swimmer's ear) and middle ear (otitis media) infections can be treated at home with remedies like warm compresses for ear pain relief, tea tree, ginger, or garlic oil drops. Symptoms of an outer ear (swimmer's ear) and middle ear infection include mild to severe ear pain, pus draining from the ear, swelling and redness in the ear, and hearing problems. Middle and inner ear infections may cause fever, and balance problems. Inner ear infections also may cause nausea, vomiting, vertigo, ringing in the ear, and labyrinthitis (inflammation of the inner ear). Most outer and middle ear infections do not need antibiotics. Inner ear infections should be treated by a doctor specializing in ear and hearing problems.
Is Laryngitis Contagious?
Laryngitis is inflammation and swelling of the voice box (larynx). Causes of laryngitis are viral, bacterial, fungal, strenuous singing or talking, chemical irritants, and other underlying medical conditions. Symptoms of laryngitis are hoarseness, a weak or loss of voice, sore throat, dry throat, a tickling sensation in the back of the throat, or irritated or raw throat. Treatment of laryngitis depends upon the cause.
Bronchitis is inflammation of the airways in the lung. Acute bronchitis is short in duration (10-20 days) in comparison with chronic bronchitis, which lasts for months to years. Causes of acute bronchitis include viruses and bacteria, which means it can be contagious. Acute bronchitis caused by environmental factors such as pollution or cigarette smoke is not contagious. Common symptoms for acute bronchitis include nasal congestion, cough, headache, sore throat, muscle aches, and fatigue. Acute bronchitis in children also my include runny nose, fever, and chest pain. Treatment for acute bronchitis are OTC pain relievers, cough suppressants (although not recommended in children), and rest. Infrequently antibiotics may be prescribed to treat acute bronchitis.
Is a Urinary Tract Infection (UTI) Contagious?
Bacteria such as E. coli or Pseudomonas can cause a urinary tract infection (UTI). The incubation period for a UTI ranges from three to eight days.
Urinary Tract Infection in Adults
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Second Source article from WebMD
Laryngitis Home Remedies
Laryngitis is an inflammation of the larynx. Inflammation of the larynx is most often caused by viral infections, and have symptoms such as sore throat, cough, problems swallowing, and fever. The voice changes produced by laryngitis may last after the fever and other symptoms of the acute infection has gone away. The best natural home remedy to relieve pain and other symptoms caused by laryngitis include resting your voice and breathing humidified air often. Turning on hot water in the bathroom and then sitting in the steam can soothe and relive laryngitis symptoms. Acetaminophen (Tylenol) and anti-inflammatory drugs (NSAIDs) like ibuprofen (Advil, Aleve) can relieve pain and inflammation caused by laryngitis. Don't give children aspirin to infants, toddlers, children and teens because of the risk of developing Reye's syndrome, which can be fatal. Home remedies like resting your voice and sitting in humidified air can cure laryngitis. Medications like anti-inflammatory drugs (NSAIDs) like ibuprofen (Advil, Aleve) and acetaminophen (Tylenol) can relieve and soothe pain and symptoms caused by laryngitis.
E. coli (0157:H7) Infection
There are many types of E. coli (Escherichia coli). E. coli can cause urinary tract and bladder infections, or lead to sepsis. E coli O157:H7 (EHEC) causes bloody diarrhea and colitis. Complications of E. coli infection include hemorrhagic diarrhea, hemolytic-uremic syndrome, and thrombotic thrombocytopenic purpura. Symptoms include severe abdominal pain and bloody diarrhea. E coli O157:H7 commonly is due to eating raw or undercooked hamburger or raw milk or dairy products.
Reflux Laryngitis (Diet, Home Remedies, Medicine)
Reflux laryngitis is caused by acid refluxing back up through the esophagus and voice box. Reflux laryngitis causes irritation and inflammation of the lining of the esophagus, larynx, and throat; and can lead to symptoms, signs, and other problems like esophagitis, sinusitis, strictures, throat clearing, swallowing problems, asthma, chronic cough, and growths on the vocal cords. Typical symptoms of reflux laryngitis include heartburn, hoarseness, or a sensation of a foreign body in the throat. Reflux laryngitis can be treated with diet chanes, OTC medication, prescription medication, and lifestyle changes.
Chronic bronchitis is a cough that occurs daily with production of sputum that lasts for at least 3 months, 2 years in a row. Causes of chronic bronchitis include cigarette smoking, inhaled irritants, and underlying disease processes (such as asthma, or congestive heart failure). Symptoms include cough, shortness of breath, and wheezing. Treatments include bronchodilators and steroids. Complications of chronic bronchitis include COPD and emphysema.
How Do You Get Rid of an Inner Ear Infection Without Antibiotics?
What Is an Inner Ear Infection? Learn whether you need antibiotics and what other treatments can help to relieve your symptoms.
Is E. coli Contagious? (Symptoms and Cure)
E. coli is an infection found worldwide. There are several subtypes of the E. coli species. E. coli spreads from person to person via contaminated food or water. Symptoms and signs of E. coli infection include diarrhea, stomach cramps, and sometimes fever. Antibiotics treat E. coli infection.
How Long Does Laryngitis Last?
What is laryngitis, and how do you know if you have laryngitis? Learn the signs of laryngitis and how to care for your throat if you have laryngitis.
What Is the Treatment for Asthmatic Bronchitis?
Asthmatic bronchitis refers to inflammation of the bronchial tubes carrying air inside the lungs that occurs because of asthma. Treatment for asthmatic bronchitis involves bronchodilators, steroids, treating secretions, leukotriene inhibitors, antibiotics, oxygen administration and avoiding triggers.
What Are the Main Causes of Bronchitis?
Bronchitis is an inflammation of the tubes that carry air to and from your lungs. Learn the signs of bronchitis, what causes bronchitis, how doctors diagnose bronchitis, and what you can do to treat bronchitis.
Urinary Tract Infections in Children
Urinary tract infections (UTIs) are very common in children. Symptoms and signs include fever and abdominal pain. Associated symptoms and signs include flank pain, vomiting, and blood in the urine. Treatment for a UTI involves antibiotic therapy.
Is Bronchitis Contagious Through Kissing?
Bronchitis is a common issue that affects many people. Learn the signs of bronchitis, what causes it, how doctors diagnose it, and what you can do to treat it.
Yeast Infection vs. Urinary Tract Infection (UTI)
Candida albicans typically causes vaginal yeast infections. Bacterial infections typically cause urinary tract infections (UTIs). Thick white cottage-cheese like vaginal discharge characterizes vaginal yeast infections. Painful, frequent urination characterize urinary tract infections. Antifungal medications treat yeast infections while prescription antibiotics treat UTIs.
How Do You Get Rid of Bronchitis Naturally?
Bronchitis is swelling of airways mostly due to a virus. Rarely, bacteria or fungi can also be the reason. Swelling in bronchial tubes may restrict air to and from your lungs. It typically causes a bad cough, chest discomfort, and fatigue. You may need to consult a doctor to distinguish bronchitis from pneumonia.
How Long Does Asthmatic Bronchitis Last?
The duration of the disease usually depends on the patient’s overall health and age. In patients with acute bronchitis symptoms may last less than 10 days. In patients with severe asthmatic bronchitis, the symptoms are recurrent and usually last between 30 days to even 2 years with flares and remissions.
Enterovirulent E. coli (EEC)
Enterovirulent Escherichia coli (E. coli) are strains of related bacteria that have a strong propensity to cause gastrointestinal tract infections. Examples of strains include: EHEC (enterohemorrhagic E. coli), ETEC (enterotoxigenic E. coli), EPEC (enteropathogenic E. coli), EIEC (enteroinvasive E. coli), EAEC (enteroadherent E. coli), and EAggEC (enteroaggregative E. coli). Symptoms may vary depending on the strain the individual contracts. Infection is spread generally through contaminated food or drink.
How Do You Know if Your Baby has Bronchitis?
Acute bronchitis, which is sometimes called a chest cold, can develop after your baby has a cold or upper respiratory infection. Bronchitis occurs when the bronchi, the airways that carry air to the lungs, become irritated and inflamed.
How Do You Know If Your Child Has Bronchitis?
Bronchitis is a common problem that affects many children. Learn the signs of bronchitis, what causes it, how doctors diagnose it, and what you can do to treat it.
How Do You Know if You Have a Urinary Tract Infection?
Urinary tract infections can occur in both women and men. Learn the signs of urinary tract infection, what causes it, how doctors diagnose it, and what you can do to treat it.
Emphysema, Chronic Bronchitis, and Colds
If you have a COPD such as emphysema, avoiding chronic bronchitis and colds is important to avoid a more severe respiratory infection such as pneumonia. Avoiding cigarette smoking, practice good hygeine, stay away from crowds, and alerting your healthcare provider if you have a sinus infection or cold or cough that becomes worse. Treatment options depend upon the severity of the emphysema, bronchitis, or cold combination.
Laryngitis: Symptoms, Causes, and Treatments
Laryngitis is the inflammation of the voice box (larynx). If caused by a virus or bacteria, laryngitis may be contagious.
Urinary Tract Infection or Urinary Infection
The urinary system of your body includes two kidneys, two tubes (ureters), a urine sac (bladder) and an opening to expel the urine from the body (urethra). An infection of this system due to germs is called a urinary tract infection (UTI). UTI may be treated with antibiotics, especially if a kidney infection is involved.
What Helps When You Have Bronchitis?
Bronchitis refers to the inflammation of the air-carrying tubes in the lungs (bronchioles). The condition is often associated with persistent, nagging cough with mucus. The condition often starts as an infection of the nose, throat, ears, or sinuses that later moves to the bronchi.
Treatment & Diagnosis
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Prevention & Wellness
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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