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Does Cardene (nicardipine) cause side effects?
In order to pump blood, the heart needs oxygen. The harder the heart works, the more oxygen it requires.
Cardene reduces the pressure in the arteries. This makes it easier for the heart to pump blood, and, as a result, the heart needs less oxygen. By reducing the heart's need for oxygen, calcium channel blockers relieve or prevent angina.
Calcium channel blockers also are used to treat high blood pressure because of their blood pressure-lowering effects. Calcium channel blockers decrease the excitability of heart muscle and are used for treating certain types of abnormally rapid heart rhythms.
Common side effects of Cardene include
Serious side effects of Cardene include
- overgrowth of the gums,
- increased heart rate due to a drop in blood pressure,
- increased frequency and duration of angina, and
- excessively low blood pressure in rare instances, especially during initiation of treatment or following adjustments of dosage.
- Itraconazole, ketoconazole, or clarithromycin may increase blood levels of Cardene by reducing its breakdown in the liver and lead to toxicity from Cardene.
- Co-administration of Cardene and cyclosporine results in increased cyclosporine blood levels.
What are the side effects of Cardene (nicardipine)?
Side effects include:
Fainting, over growth of the gums, and rash also may occur. It may increase heart rate due to a drop in blood pressure. Nicardipine sometimes causes an increase in the frequency and duration of angina.
The reason for this side effect is not clearly understood. Excessively low blood pressure can occur in rare instances, especially during initiation of treatment or following adjustments of dosage.
Cardene (nicardipine) side effects list for healthcare professionals
In multiple-dose US and foreign controlled studies, 667 patients received Cardene SR. In these studies adverse events were elicited by non-directed and in some cases directed questioning; adverse events were generally not serious and about 9% of patients withdrew prematurely from the studies because of them.
The incidence rates of adverse events in hypertensive patients were derived from placebo-controlled clinical trials. Following are the rates of adverse events for Cardene SR (n=322) and placebo (n=140), respectively, that occurred in 0.6% of patients or more on Cardene SR.
These represent events considered probably drug related by the investigator. Where the frequency of adverse events for Cardene SR and placebo is similar, causal relationship is uncertain. The only dose-related effect was pedal edema.
Percentage of Patients With Probably Drug Related Adverse Events in Placebo-Controlled Studies
|Adverse Event||Cardene SR (n=322)||Placebo (n=140)|
Incidence (%) of Discontinuations Due to Any Adverse Event in Placebo-Controlled Studies
|Adverse Event||Cardene SR (n=322)||Placebo (n=140)|
Uncontrolled experience in over 300 patients with hypertension treated for up to 27.5 months with Cardene SR has shown no unexpected adverse events or increase in incidence of adverse events compared to the controlled clinical trials.
The following rare adverse events have been reported in clinical trials or the literature:
Body as a Whole: infection, allergic reaction
Digestive: sore throat, abnormal liver chemistries
Data are available from only 91 patients with chronic stable angina pectoris who received Cardene SR 30 to 60 mg administered twice daily in open-label clinical trials. Fifty-eight of these patients were treated for at least 30 days.
The four most frequently reported adverse events thought by the investigators to be probably related to the use of Cardene SR were
- vasodilatation (5.5%),
- pedal edema (4.4%),
- asthenia (4.4%), and
- dizziness (3.3%).
What drugs interact with Cardene (nicardipine)?
In controlled clinical studies, adrenergic beta-receptor blockers have been frequently administered concomitantly with Cardene. The combination is well tolerated.
Some calcium blockers may increase the concentration of digitalis preparations in the blood. Cardene usually does not alter the plasma levels of digoxin; however, serum digoxin levels should be evaluated after concomitant therapy with Cardene is initiated.
Severe hypotension has been reported during fentanyl anesthesia with concomitant use of a beta-blocker and a calcium channel blocker. Even though such interactions were not seen during clinical studies with Cardene, an increased volume of circulating fluids might be required if such an interaction were to occur.
Concomitant administration of nicardipine and cyclosporine results in elevated plasma cyclosporine levels. Plasma concentrations of cyclosporine should therefore be closely monitored, and its dosage reduced accordingly, in patients treated with nicardipine.
Cardene (nicardipine) is a calcium channel blocker (CCB) used to treat high blood pressure (hypertension) and angina (heart pain). Common side effects of Cardene include swelling of the feet (edema), dizziness, headaches, flushing, palpitations, and nausea. There are no adequate studies of Cardene in pregnant women. Animal studies show Cardene is secreted in breast milk. Cardene should be avoided by breastfeeding mothers.
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Related Disease Conditions
High Blood Pressure (Hypertension)
High blood pressure (hypertension) is a disease in which pressure within the arteries of the body is elevated. About 75 million people in the US have hypertension (1 in 3 adults), and only half of them are able to manage it. Many people do not know that they have high blood pressure because it often has no has no warning signs or symptoms. Systolic and diastolic are the two readings in which blood pressure is measured. The American College of Cardiology released new guidelines for high blood pressure in 2017. The guidelines now state that blood normal blood pressure is 120/80 mmHg. If either one of those numbers is higher, you have high blood pressure. The American Academy of Cardiology defines high blood pressure slightly differently. The AAC considers 130/80 mm Hg. or greater (either number) stage 1 hypertension. Stage 2 hypertension is considered 140/90 mm Hg. or greater. If you have high blood pressure you are at risk of developing life threatening diseases like stroke and heart attack.REFERENCE: CDC. High Blood Pressure. Updated: Nov 13, 2017.
Hypertension-Related Kidney Disease
Second Source WebMD Medical Reference
High Blood Pressure Treatment (Natural Home Remedies, Diet, Medications)
High blood pressure (hypertension) means high pressure (tension) in the arteries. Treatment for high blood pressure include lifestyle modifications (alcohol, smoking, coffee, salt, diet, exercise), drugs and medications such as ACE inhibitors, angiotensin receptor blockers, beta blockers, diuretics, calcium channel blockers (CCBs), alpha blockers, clonidine, minoxidil, and Exforge.
Portal hypertension is most commonly caused by cirrhosis, a disease that results from scarring of the liver. Other causes of portal hypertension include blood clots in the portal vein, blockages of the veins that carry the blood from the liver to the heart, and a parasitic infection called schistosomiasis. Symptoms of portal hypertension include varices (enlarged veins), vomiting blood, blood in the stool, black and tarry stool, ascites (abnormal fluid collection within the peritoneum, the sac that contains the intestines within the abdominal cavity), confusion and lethargy, splenomegaly or enlargement of the spleen, and decreased white blood cell counts.
Hypertensive Kidney Disease
High blood pressure can damage the kidneys and is one of the leading causes of kidney failure (end-stage renal kidney disease). Kidney damage, like hypertension, can be unnoticeable and detected only through medical tests. If you have kidney disease, you should control your blood pressure. Other treatment options include prescription medications.
Pulmonary hypertension is elevated pressure in the pulmonary arteries that carry blood from the lungs to the heart. The most common symptoms are fatigue and difficulty breathing. If the condition goes undiagnosed, more severe symptoms may occur. As pulmonary hypertension worsens, some people with the condition have difficulty performing any activities that require physical exertion. While there is no cure for pulmonary hypertension, it can be managed and treated with medications and supplemental oxygen to increase blood oxygen levels.
Pseudotumor Cerebri (Idiopathic Intracranial Hypertension)
Pseudotumor Cerebri (intracranial hypertension) is a condition where there is an increase in pressure of fluid surrounding the brain and spinal cord (cerebrospinal fluid or CSF) mimicing a brain tumor. The cause is unknown. The most common symptom is headache but also include eye-pain, vision loss and double vision. Pseudotumor cerebri is diagnosed with MRI or CAT scans and treated by discontinuing offending medications (if applicable), weight loss and diuretic medications. The condition can also be helped by repeated drainage of spinal fluid using the lumbar puncture.
Preeclampsia (Pregnancy Induced Hypertension)
Preeclampsia is related to increased blood pressure and protein in the mother's urine. Preeclampsia typically begins after the 20th week of pregnancy. When preeclampsia causes seizures, it is termed "eclampsia" and is the second leading cause of maternal death of in the US. Preeclampsia is the leading cause of fetal complications. Risk factors for preeclampsia include high blood pressure, obesity, multiple births, and women with preexisting medical conditions such as diabetes, kidney disease, rheumatoid arthritis, lupus, or scleroderma. Pregnancy planning and lifestyle changes may reduce the risk of preeclampsia during pregnancy.
High Blood Pressure Symptoms
Most people with high blood pressure have no signs or symptoms, even if blood pressure readings reach dangerously high levels. In some patients, symptoms may include fatigue, headaches, dizziness, confusion, sweating, chest pain and vision problems.
What Is High Blood Pressure (Hypertension)?
High blood pressure or hypertension is when the blood pressure readings consistently range from 140 or higher for systolic or 90 or higher for diastolic. Blood pressure readings above 180/120 mmHg are dangerously high and require immediate medical attention.
Treatment & Diagnosis
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Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.