Does Hemabate (carboprost) cause side effects?
Hemabate (carboprost) is a man-made oxytocic medication that mimics the action of a naturally occurring chemical called prostaglandin F2 alpha and is used to abort pregnancy during the second trimester and to treat uterine bleeding after delivery.
Common side effects of Hemabate include
Serious side effects of Hemabate include
- inflammation of the lining of the uterus (endometritis),
- retained placental fragments,
- excessive uterine bleeding, and
- hypersensitivity with allergic reactions.
Oxytocin also induces contractions during labor; therefore, the use of both medications is not recommended. Hemabate should be used only for termination of pregnancy and to treat hemorrhage after delivery.
What are the important side effects of Hemabate (carboprost)?
Common side effects of carboprost are:
It also may cause:
- Endometritis (inflammation of the lining of the uterus)
- Retained placental fragments
- Excessive uterine bleeding
Hypersensitivity with allergic reactions may occur. Therefore, patients must be under medical supervision while carboprost is being administered.
Hemabate (carboprost) side effects list for healthcare professionals
The adverse effects of Hemabate Sterile Solution are generally transient and reversible when therapy ends. The most frequent adverse reactions observed are related to its contractile effect on smooth muscle.
In patients studied, approximately two-thirds experienced vomiting and diarrhea, approximately onethird had nausea, one-eighth had a temperature increase greater than 2° F, and one-fourteenth experienced flushing.
The pretreatment or concurrent administration of antiemetic and antidiarrheal drugs decreases considerably the very high incidence of gastrointestinal effects common with all prostaglandins used for abortion. Their use should be considered an integral part of the management of patients undergoing abortion with Hemabate.
Of those patients experiencing a temperature elevation, approximately one-sixteenth had a clinical diagnosis of endometritis. The remaining temperature elevations returned to normal within several hours after the last injection.
Adverse effects observed during the use of Hemabate for abortion and for hemorrhage, not all of which are clearly drug related, in decreasing order of frequency include:
|Flushing or hot flashes||Dyspnea|
|Chills or shivering||Tightness in chest|
|Headaches||Posterior cervical perforation|
|Muscular pain||Excessive thirst|
|Breast tenderness||Twitching eyelids|
|Eye pain||Gagging, retching|
|Dystonia||Sensation of choking|
|Injection site pain||Syncope|
|Vaso-vagal syndrome||Upper respiratory infection|
|Dryness of mouth||Leg cramps|
|Taste alterations||Retained placental fragment|
|Urinary tract infection||Shortness of breath|
|Septic shock||Fullness of throat|
|Endometritis from IUCD|
The most common complications when Hemabate was utilized for abortion requiring additional treatment after discharge from the hospital were endometritis, retained placental fragments, and excessive uterine bleeding, occurring in about one in every 50 patients.
Hemabate (carboprost) is a man-made oxytocic medication that mimics the action of a naturally occurring chemical called prostaglandin F2 alpha and is used to abort pregnancy during the second trimester and to treat uterine bleeding after delivery. Common side effects of Hemabate include nausea, vomiting, diarrhea, fever, and flushing. Hemabate should be used only for termination of pregnancy and to treat hemorrhage after delivery. It is unknown if Hemabate is excreted in breast milk.
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Treatment & Diagnosis
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Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.