- Heart Disease (Coronary Artery Disease) Slideshow Pictures
- Atrial Fibrillation Slideshow: Causes, Tests and Treatment
- Take the Heart Disease Quiz!
Does Bumex (bumetanide) cause side effects?
Bumex (bumetanide) is a potent diuretic (water pill) that causes a profound increase in urine output (diuresis) by preventing the kidney from retaining fluid in people with congestive heart failure, liver disease or kidney disorder. Specifically, it blocks the reabsorption of sodium and fluid from the kidney's tubules.
It is in a class of diuretics called "loop" diuretics which also includes furosemide (Lasix) and torsemide (Demadex). One mg of bumetanide is approximately equivalent to 10-20 mg of torsemide and 40 mg of furosemide.
The potent diuretic effect of Bumex can cause the loss of large amounts of body water leading to dehydration as well as the loss of electrolytes (for example, sodium, potassium, magnesium, and calcium). Careful medical supervision is necessary during treatment.
Common side effects of Bumex include
- low blood levels of potassium,
- sodium and
Serious side effects of Bumex include
- fluid losses that can lead to dehydration (symptoms of dehydration may include dry mouth, thirst, weakness, drowsiness, reduced kidney function, heart arrhythmias, muscle aches and pains, nausea, and vomiting),
- toxicity to the inner ear in the form of ringing in the ear (tinnitus) and hearing loss, and
- high uric acid concentrations in the blood leading to attacks of gouty arthritis.
- The body's ability to eliminate lithium may decrease in patients receiving Bumex. Careful monitoring of lithium levels in blood is recommended when Bumex and lithium are taken together in order to prevent increases in lithium levels and lithium toxicity.
- Indomethacin can reduce the diuretic and blood pressure-lowering effects of other loop diuretics (for example furosemide) and it probably can do the same with Bumex.
- Other nonsteroidal anti-inflammatory drugs (NSAIDs), for example, ibuprofen and naproxen, may interact similarly. Concomitant use of Bumex and aminoglycosides may increase the risk of hearing impairment since both agents can affect hearing.
There have been no adequate studies on the effects of Bumex on the fetus. The physician must carefully weigh the potential but unknown risks and benefits of Bumex before prescribing it for pregnant women.
What are the important side effects of Bumex (bumetanide)?
Potent diuretics like bumetanide can cause low blood levels of potassium, magnesium, sodium and calcium. Additionally, fluid losses can occur leading to dehydration.
The symptoms of dehydration may include:
- dry mouth,
- reduced kidney function,
- heart arrhythmias,
- muscle aches and pains,
- nausea, and
Toxicity to the inner ear in the form of tinnitus (ringing in the ear) and hearing loss have been associated with loop diuretics. High plasma levels of bumetanide are toxic to the inner ear of animals. These effects on the inner ear are far more common with intravenous use of the drugs. High uric acid concentrations in the blood leading to attacks of gouty arthritis may occur during diuretic therapy.
Bumex (bumetanide) side effects list for healthcare professionals
The most frequent clinical adverse reactions considered probably or possibly related to Bumex are
- muscle cramps (seen in 1.1% of treated patients),
- dizziness (1.1%),
- hypotension (0.8%),
- headache (0.6%),
- nausea (0.6%) and
- encephalopathy (in patients with preexisting liver disease) (0.6%).
One or more of these adverse reactions have been reported in approximately 4.1% of patients treated with Bumex.
Less frequent clinical adverse reactions to Bumex are
- impaired hearing (0.5%),
- pruritus (0.4%),
- electrocardiogram changes (0.4%),
- weakness (0.2%),
- hives (0.2%),
- abdominal pain (0.2%),
- arthritic pain (0.2%),
- musculoskeletal pain (0.2%),
- rash (0.2%) and
- vomiting (0.2%).
One or more of these adverse reactions have been reported in approximately 2.9% of patients treated with Bumex.
Other clinical adverse reactions, which have each occurred in approximately 0.1% of patients, are
- chest pain,
- ear discomfort,
- dry mouth,
- upset stomach,
- renal failure,
- nipple tenderness,
- premature ejaculation and
- difficulty maintaining an erection.
Laboratory abnormalities reported have included
- hyperuricemia (in 18.4% of patients tested),
- hypochloremia (14.9%),
- hypokalemia (14.7%),
- azotemia (10.6%),
- hyponatremia (9.2%),
- increased serum creatinine (7.4%),
- hyperglycemia (6.6%), and
- variations in
Although manifestations of the pharmacologic action of Bumex, these conditions may become more pronounced by intensive therapy.
There have been rare spontaneous reports of thrombocytopenia from postmarketing experience.
Diuresis induced by Bumex may also rarely be accompanied by changes in LDH (1.0%), total serum bilirubin (0.8%), serum proteins (0.7%), SGOT (0.6%), SGPT (0.5%), alkaline phosphatase (0.4%), cholesterol (0.4%) and creatinine clearance (0.3%). Increases in urinary glucose (0.7%) and urinary protein (0.3%) have also been seen.
To report SUSPECTED ADVERSE REACTIONS, contact Validus Pharmaceuticals, LLC at 1-866-982-5438 (1-866-9VALIDUS) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
What drugs interact with Bumex (bumetanide)?
Drugs With Ototoxic Potential
- Especially in the presence of impaired renal function, the use of parenterally administered bumetanide in patients to whom aminoglycoside antibiotics are also being given should be avoided, except in life-threatening conditions.
Drugs With Nephrotoxic Potential
- There has been no experience with the concurrent use of Bumex with drugs known to have a nephrotoxic potential. Therefore, the simultaneous administration of these drugs should be avoided.
- Lithium should generally not be given with diuretics (such as Bumex) because they reduce its renal clearance and add a high risk of lithium toxicity.
- Pretreatment with probenecid reduces both the natriuresis and hyperreninemia produced by Bumex.
- This antagonistic effect of probenecid on Bumex natriuresis is not due to a direct action on sodium excretion but is probably secondary to its inhibitory effect on renal tubular secretion of bumetanide. Thus, probenecid should not be administered concurrently with Bumex.
- Indomethacin blunts the increases in urine volume and sodium excretion seen during Bumex treatment and inhibits the bumetanide-induced increase in plasma renin activity. Concurrent therapy with Bumex is thus not recommended.
- Bumex may potentiate the effect of various antihypertensive drugs, necessitating a reduction in the dosage of these drugs.
- Interaction studies in humans have shown no effect on digoxin blood levels.
Multimedia: Slideshows, Images & Quizzes
Fatty Liver Disease: Nonalcoholic, Alcoholic Symptoms and Treatment
You can treat fatty liver disease with diet and exercise. Learn the signs and symptoms of fatty liver disease, whether it is...
Heart Failure Quiz
What is heart failure? Learn about this dangerous condition, as well as who is at risk, and what to do about it.
Liver Disease Quiz: Fatty Liver Disease, Cirrhosis & Symptoms
What is liver disease? Take the Liver Disease Quiz and test your knowledge about this organ and its function.
Kidney Disease Quiz: Test Your Medical IQ
Kidney disease is common. Take this kidney disease quiz to test your knowledge and learn the symptoms, causes and types of kidney...
Heart Disease: Best and Worst Foods for Heart Failure
Learn which dietary changes help your heart, and which ones make it work harder.
Related Disease Conditions
Liver disease can be cause by a variety of things including infection (hepatitis), diseases, for example, gallstones, high cholesterol or triglycerides, blood flow obstruction to the liver, and toxins (medications and chemicals). Symptoms of liver disease depends upon the cause and may include nausea, vomiting, upper right abdominal pain, and jaundice. Treatment depends upon the cause of the liver disease.
Congestive Heart Failure (CHF)
Congestive heart failure (CHF) refers to a condition in which the heart loses the ability to function properly. Heart disease, high blood pressure, diabetes, myocarditis, and cardiomyopathies are just a few potential causes of congestive heart failure. Signs and symptoms of congestive heart failure may include fatigue, breathlessness, palpitations, angina, and edema. Physical examination, patient history, blood tests, and imaging tests are used to diagnose congestive heart failure. Treatment of heart failure consists of lifestyle modification and taking medications to decrease fluid in the body and ease the strain on the heart. The prognosis of a patient with congestive heart failure depends on the stage of the heart failure and the overall condition of the individual.
Drug-Induced Liver Disease
Drug-induced liver diseases are diseases of the liver that are caused by: physician-prescribed medications, OTC medications, vitamins, hormones, herbs, illicit (recreational) drugs, and environmental toxins. Read about the signs and symptoms of drug-induced liver disease like hepatitis (inflammation of the liver cells), liver disease treatment, and types.
What Are the 5 Stages of Chronic Kidney Disease?
The doctor will take your complete medical history along with your family history, such as if anyone in your family has or had diabetes, whether you are on any medications (that can cause kidney damage), and so on. They will perform a thorough physical examination to see if you have any signs or symptoms of CKD.
What Are the 4 Stages of Congestive Heart Failure?
The New York Heart Association developed the four stages of congestive heart failure depending on the functional capabilities of the heart which includes Class I, Class II, Class III, and Class IV.
Heart failure (congestive) is caused by many conditions including coronary artery disease, heart attack, cardiomyopathy, and conditions that overwork the heart. Symptoms of heart failure include congested lungs, fluid and water retention, dizziness, fatigue and weakness, and rapid or irregular heartbeats. There are two types of congestive heart failure, systolic or left-sided heart failure; and diastolic or right-sided heart failure. Treatment, prognosis, and life-expectancy for a person with congestive heart failure depends upon the stage of the disease.
What Are the Signs That Something Is Wrong With My Kidneys?
Most of the signs of kidney diseases are unnoticed, ignored, or appear very late in the disease. Over 37 million American adults have kidney diseases, and most are not aware of it.
Hypertension-Related Kidney Disease
Second Source WebMD Medical Reference
Second Source article from Government
Inherited Liver Diseases
Second Source WebMD Medical Reference
Hypertensive Kidney Disease
High blood pressure can damage the kidneys and is one of the leading causes of kidney failure (end-stage renal kidney disease). Kidney damage, like hypertension, can be unnoticeable and detected only through medical tests. If you have kidney disease, you should control your blood pressure. Other treatment options include prescription medications.
Polycystic Kidney Disease (PKD), ARPKD, and ADPKD
Polycystic kidney disease (PKD) is characterized by numerous cysts in the kidneys. Polycystic kidney disease is a genetic disorder. There are two major inherited forms of PKD, autosomal dominant PKD, and autosomal recessive PKD. Symptoms include headaches, urinary tract infections, blood in the urine, liver and pancreatic cysts, abnormal heart valves, high blood pressure, kidney stones, aneurysms, and diverticulosis. Diagnosis of PKD is generally with ultrasound, CT or MRI scan. There is no cure for PKD, so treatment of symptoms is usually the general protocol.
Diabetes and Kidney Disease
In the United States diabetes is the most common cause of kidney failure. High blood pressure and high levels of blood glucose increase the risk that a person with diabetes will eventually progress to kidney failure. Kidney disease in people with diabetes develops over the course of many years. albumin and eGFR are two key markers for kidney disease in people with diabetes. Controlling high blood pressure, blood pressure medications, a moderate protein diet, and compliant management of blood glucose can slow the progression of kidney disease. For those patients who's kidneys eventually fail, dialysis or kidney transplantation is the only option.
What Causes Congestive Heart Failure?
Congestive heart failure is a chronic disease that progresses with time if left untreated. Heart failure can occur due to diseases of the heart, the blood vessels supplying oxygen and nutrients to the heart, or sometimes from factors outside the heart (extracardiac causes). With proper management, people who have congestive heart failure can lead nearly normal lives, depending on the severity of the condition.
Hypertension-Induced Chronic Kidney Disease
Hypertension-induced chronic kidney disease (CKD) is a long-standing kidney condition that develops over time due to persistent or uncontrolled high blood pressure (hypertension).
Treatment & Diagnosis
- Kidney Disease FAQs
- Liver Disease FAQs
- Heart Failure FAQs
- Polycystic Kidney Disease Gene Isolated
- Heart Failure ... Old Drug, New Therapy
- Smoking With Liver Disease - A No-No
- Heart Failure: What Killed George Carlin?
- Elizabeth Taylor Dies of Congestive Heart Failure
- What Are Risk Factors for Diabetic Kidney Disease?
- How Do You Check for Congestive Heart Failure?
- Congestive Heart Failure Treatment
- Congestive Heart Failure Symptoms
Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.