Does Aygestin (norethindrone) cause side effects?
Common side effects of Aygestin include
- fluid retention (edema),
- breast tenderness,
- irregular menstrual cycle,
- breakthrough bleeding,
- weight changes, and
Serious side effects of Aygestin include
No drug-drug interactions have been conducted and established with Aygestin.
Aygestin is not recommended for pregnant mothers under any circumstances. Aygestin may cause birth defects. Aygestin may enter in breast milk in trace amounts. It should be used with extreme caution in breastfeeding mothers.
Aygestin (norethindrone) side effects list for healthcare professionals
The following adverse reactions have been observed in women taking progestins:
- Breakthrough bleeding
- Change in menstrual flow
- Changes in weight (decreases, increases)
- Changes in the cervical squamo-columnar junction and cervical secretions
- Cholestatic jaundice
- Rash (allergic) with and without pruritus
- Melasma or chloasma
- Clinical depression
- Breast enlargement/tenderness
- Abnormalities of liver tests (i.e., AST, ALT, Bilirubin)
- Decreased HDL cholesterol and increased LDL/HDL ratio
- Mood swings
- Anaphylactic/anaphylactoid reactions
- Thrombotic and thromboembolic events (e.g., deep vein thrombosis, pulmonary embolism, retinal vascular thrombosis, cerebral thrombosis and embolism)
- Optic neuritis (which may lead to partial or complete loss of vision)
What drugs interact with Aygestin (norethindrone)?
Drug/Laboratory Tests Interactions
- Accelerated prothrombin time, partial thromboplastin time, and platelet aggregation time; increased platelet count; increased factors II, VII antigen, VIII antigen, VIII coagulant activity, IX, X, XII, VII-X complex, II-VII-X complex, and beta-thromboglobulin; decreased levels of antifactor Xa and antithrombin III, decreased antithrombin III activity; increased levels of fibrinogen and fibrinogen activity; increased plasminogen antigen and activity.
- Increased thyroid-binding globulin (TBG) levels leading to increased circulating total thyroid hormone levels as measured by protein-bound iodine (PBI), T4 levels (by column or by radioimmunoassay) or T3 levels by radioimmunoassay. T3 resin uptake is decreased, reflecting the elevated TBG. Free T4 and free T3 concentrations are unaltered. Patients on thyroid replacement therapy may require higher doses of thyroid hormone.
- Other binding proteins may be elevated in serum (i.e., corticosteroid binding globulin (CBG), sex hormone binding globulin (SHBG)) leading to increased circulating corticosteroid and sex steroids, respectively. Free or biologically active hormone concentrations are unchanged. Other plasma proteins may be increased (angiotensinogen/renin substrate, alpha-1-antitrypsin, ceruloplasmin).
- Increased plasma HDL and HDL2 cholesterol subfraction concentrations, reduced LDL cholesterol concentration, increased triglycerides levels.
- Impaired glucose metabolism.
- Reduced response to metyrapone test.
Aygestin (norethindrone) is a man-made form of the female hormone progestin used to treat abnormal uterine bleeding and related conditions (such as amenorrhea and endometriosis). Common side effects of Aygestin include fluid retention (edema), nausea, breast tenderness, irregular menstrual cycle, breakthrough bleeding, spotting, weight changes, and headache. Serious side effects of Aygestin include deep vein thrombosis and depression. Aygestin may cause birth defects. Aygestin may enter in breast milk in trace amounts.
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Related Disease Conditions
Endometriosis implants are most commonly found on the ovaries, the Fallopian tubes, outer surfaces of the uterus or intestines, and on the surface lining of the pelvic cavity. They also can be found in the vagina, cervix, and bladder. Endometriosis may not produce any symptoms, but when it does the most common symptom is pelvic pain that worsens just prior to menstruation and improves at the end of the menstrual period. Other symptoms of endometriosis include pain during sex, pain with pelvic examinations, cramping or pain during bowel movements or urination, and infertility. Treatment of endometriosis can be with medication or surgery.
Uterine Fibroids (Benign Tumors of the Uterus)
Uterine fibroids are benign (non-cancerous) tumors in the womb (uterus). Most uterine fibroids do not cause symptoms; however, if the fibroid is large enough and in the right location, it may cause symptoms of pelvic pain, abnormal vaginal bleeding, and pressure on the bladder or rectum. Uterine fibroids that remain small and do not grow usually do not need treatment; however, surgery to remove the fibroid may be necessary. Uterine fibroids do not cause cancer; however, there is a rare, fast-growing cancerous called leiomyosarcoma.
Benign uterine growths are tissue enlargements of the female womb (uterus). Three types of benign uterine growths are uterine fibroids, adenomyosis, and uterine polyps. Symptoms include abdominal pressure and pain, pelvic pain, pain during intercourse, and pain during bowel movements. Diagnosis and treatment of benign uterine growths depends upon the type of growth.
Amenorrhea (including hypothalmic amenorrhea) is a condition in which there is an absence of menstrual periods in a woman. There are two types of amenorrhea: primary and secondary. Treatment of amenorrhea depends on the type. In primary, surgery may be an option and in secondary amenorrhea medication or lifestyle changes may be treatment options. We go over the definition of amenorrhea, causes, and treatment options for amenorrhea.
How Do I Know If I Have Endometriosis?
Approximately, one-third of the women with endometriosis remain asymptomatic. Severe pain during menses may be the first sign of endometriosis. Other symptoms that you may experience include heavy periods, low back pain, cramps, pain during intercourse and other symptoms.
What Are the Early Signs of Endometriosis?
The endometrium is the inner lining of the uterus, which changes throughout the menstrual cycle, shedding during menstrual periods. Endometriosis is the presence of normal endometrial tissue abnormally implanted in locations other than the inner wall of the uterus. This causes pain and other symptoms that may include infertility.
Treatment & Diagnosis
Medications & Supplements
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.