What is Anturane (sulfinpyrazone)?
Anturane (sulfinpyrazone) is an auricosuric agent used to treat gout. Gout is caused by elevated blood levels of uric acid (hyperuricemia).
Anturane works by increasing the excretion of uric acid in the urine thereby lowering the elevated levels of uric acid in the blood that are responsible for gout. The brand name Anturane is discontinued in the U.S.
Side effects of Anturane are uncommon and usually mild, including:
- stomach upset.
Combining the drug with food, milk, or antacids is advised.
Serious side effects of Anturane include:
- kidney pain,
- uric acid kidney stones, and
- severe anemias (rare).
There are no listed drug interactions of Anturane. Tell your doctor all medications and supplements you use.
Anturane should be used with caution in pregnant women, weighing the potential risks against the possible benefits. Consult your doctor before breastfeeding.
What are the important side effects of Anturane (sulfinpyrazone)?
Side effects of sulfinpyrazone are uncommon and usually mild. The most frequent adverse reaction is stomach upset.
Accordingly, is advised to combine the drug with:
- milk or
Sulfinpyrazone, however, can cause kidney pain and uric acid kidney stones. Rarely, it has caused severe anemias.
Anturane (sulfinpyrazone) side effects list for healthcare professionals
The most frequently reported adverse reactions with Anturane (sulfinpyrazone) have been upper gastrointestinal disturbances.
In these patients it is advisable to administer the drug with food, milk, or antacids. Despite this precaution, Anturane (sulfinpyrazone) may aggravate or reactivate peptic ulcer.
Rash has been reported. In most instances, this reaction did not necessitate discontinuance of therapy. In general, Anturane (sulfinpyrazone) has not been observed to affect electrolyte balance.
Side effects that have rarely been reported include:
- blood dyscrasias (anemia, leukopenia, agranulocytosis, thrombocytopenia, and aplastic anemia).
There has also been a published report associating Anturane (sulfinpyrazone) , administered concomitantly with other drugs including colchicine, with leukemia following long term treatment of patients with gout. However, the circumstances involved in the two cases reported are such that a cause-and-effect relationship to Anturane (sulfinpyrazone) has not been clearly established.
Anturane (sulfinpyrazone) is an auricosuric agent used to treat gout. Gout is caused by elevated blood levels of uric acid (hyperuricemia). Side effects of Anturane uncommon and usually mild and include stomach upset. Combining the drug with food, milk, or antacids is advised. Serious side effects of Anturane include kidney pain, uric acid kidney stones, and severe anemias (rare). There are no listed drug interactions of Anturane. Tell your doctor all medications and supplements you use. Anturane should be used with caution in pregnant women, weighing the potential risks against the possible benefits. Consult your doctor before breastfeeding.
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Related Disease Conditions
Buildup of uric acid crystals in a joint causes gouty arthritis. Symptoms and signs include joint pain, swelling, heat, and redness, typically of a single joint. Gout may be treated with diet and lifestyle changes, as well as medication.
Pseudogout, a form of arthritis, results when deposits of crystals collect in and around the joints. Symptoms of pseudogout include pain, stiffness, warmth, and joint swelling of the knees, ankles, hips, shoulders, and/or wrists. Treatment for pseudogout aims to decrease inflammation through the use of nonsteroidal anti-inflammatory drugs, ice, and rest.
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects and drug interactions sections courtesy of the U.S. Food and Drug Administration.