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Does Adipex-P (phentermine) cause side effects?
Adipex-P (phentermine) is an appetite suppressant prescribed, combined with diet and exercise, for the short-term treatment of obesity in individuals with a body mass index greater than or equal to 30 kg/m2 or greater than or equal to 27 kg/m2 with risk factors for heart disease.
Adipex-P should not be combined with other weight loss agents. The combination of phentermine and fenfluramine (FEN-PHEN) is associated with serious heart problems. Fenfluramine is no longer available in the U.S.
Common side effects of Adipex-P include
- dry mouth,
- unpleasant taste,
- high blood pressure,
- fast heart rates (palpitations), and
- central nervous system side effects (hyperactivity, insomnia, restlessness, tremor, and dizziness).
Serious side effects of Adipex-P include
- high pressures in the pulmonary arteries (pulmonary hypertension) and
- defects in heart valves (especially when combined with fenfluramine).
Physical and psychological dependence may occur with the long-term use of Adipex-P. Withdrawal reaction may occur after prolonged uses, including
Drug interactions of Adipex-P include tricyclic antidepressants and monoamine oxidase inhibitors (MAOIs) may result in high blood pressure and other serious reactions because of elevated serotonin levels in the blood.
Adipex-P should not be used within 14 days after stopping a monoamine oxidase inhibitor.
Combining alcohol with Adipex-P may result in an adverse drug reaction.
Use of Adipex-P during pregnancy has not been adequately evaluated. It is unknown if Adipex-P is excreted in human breast milk. Since other amphetamines are excreted in breast milk, Adipex-P should not be used while breastfeeding.
What are the important side effects of Adipex-P (phentermine)?
Side effects of phentermine include:
- dry mouth,
- an unpleasant taste,
- high blood pressure, and
- fast heart rates (palpitations).
Central nervous system side effects include:
Phentermine, especially when combined with fenfluramine, has been associated with high pressures in the pulmonary arteries (pulmonary hypertension) and defects in heart valves, both serious complications.
Physical and psychological dependence may occur with the long-term use of phentermine. A withdrawal reaction, which includes excessive drowsiness, fatigue, tremors and depression may occur after prolonged use.
Adipex-P (phentermine) side effects list for healthcare professionals
The following adverse reactions are described, or described in greater detail, in other sections:
- Primary pulmonary hypertension
- Valvular heart disease
- Effect on the ability to engage in potentially hazardous tasks
- Withdrawal effects following prolonged high dosage administration
The following adverse reactions to phentermine have been identified:
Central Nervous System
Impotence, changes in libido.
What drugs interact with Adipex-P (phentermine)?
Monoamine Oxidase Inhibitors
Use of Adipex-P is contraindicated during or within 14 days following the administration of monoamine oxidase inhibitors because of the risk of hypertensive crisis.
Concomitant use of alcohol with Adipex-P may result in an adverse drug reaction.
Insulin And Oral Hypoglycemic Medications
Requirements may be altered.
Adrenergic Neuron Blocking Drugs
Adipex-P may decrease the hypotensive effect of adrenergic neuron blocking drugs.
Does Adipex-P (phentermine) cause addiction or withdrawal symptoms?
Drug Abuse And Dependence
Phentermine is a Schedule IV controlled substance.
Phentermine is related chemically and pharmacologically to the amphetamines. Amphetamines and other stimulant drugs have been extensively abused and the possibility of abuse of phentermine should be kept in mind when evaluating the desirability of including a drug as part of a weight reduction program.
Abuse of amphetamines and related drugs may be associated with intense psychological dependence and severe social dysfunction.
There are reports of patients who have increased the dosage of these drugs to many times that recommended. Abrupt cessation following prolonged high dosage administration results in extreme fatigue and mental depression; changes are also noted on the sleep EEG.
Manifestations of chronic intoxication with anorectic drugs include severe dermatoses, marked insomnia, irritability, hyperactivity and personality changes. A severe manifestation of chronic intoxication is psychosis, often clinically indistinguishable from schizophrenia.
Adipex-P (phentermine) is an appetite suppressant prescribed, combined with diet and exercise, for the short-term treatment of obesity in individuals with a body mass index greater than or equal to 30 kg/m2 or greater than or equal to 27 kg/m2 with risk factors for heart disease. Common side effects of Adipex-P include nausea, vomiting, diarrhea, dry mouth, constipation, unpleasant taste, hives, impotence, palpitations, high blood pressure, fast heart rates (palpitations), and central nervous system side effects (hyperactivity, insomnia, restlessness, tremor, and dizziness). Use of Adipex-P during pregnancy has not been adequately evaluated. It is unknown if Adipex-P is excreted in human breast milk.
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Professional side effects, drug interactions, and addiction sections courtesy of the U.S. Food and Drug Administration.