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What is secukinumab? What is secukinumab used for?
Secukinumab is an injectable biologic drug that suppresses the immune system and is used for the treatment of psoriasis.
It is an antibody that binds to interleukin 17A (IL-17A), a chemical produced by cells in the body that stimulates immune reactions. Scientists believe that psoriasis is caused by an increase in the production of T-lymphocytes in response to the attachment of a stimulant, such as interleukin, to the lymphocyte. Stimulated T-lymphocytes cause skin cells to grow rapidly, and the rapid growth of the skin cells produces the skin plaques of psoriasis.
Secukinumab reduces symptoms of psoriasis (inflammation and excessive production of skin cells) by attaching to IL-17A, preventing it from binding and activating T-lymphocytes. The FDA approved secukinumab in January, 2015.
What brand names are available for secukinumab?
Is secukinumab available as a generic drug?
Do I need a prescription for secukinumab?
What are the side effects of secukinumab?
The most common side effects of secukinumab are:
Secukinumab may reduce the ability of the immune system to fight infections, increasing the risk of infections such as tuberculosis (TB), and infections caused by bacteria, fungi, or viruses. It also may cause a flare up of Crohn's disease. The cap of the Sensoready pen and the prefilled syringe in which secukinumab is packaged contains natural rubber latex which may cause an allergic reaction in latex-sensitive people.
What is the dosage for secukinumab?
The recommended dose is 300 mg injected under the skin at weeks 0, 1, 2, 3 and 4 followed by 300 mg every 4 weeks. For some patients, a dose of 150 mg may be acceptable.
Which drugs or supplements interact with secukinumab?
Live vaccines should not be administered to patients treated with secukinumab because they may develop active disease from the live viruses contained in the vaccine because of their weakened immune system. Vaccine containing killed virus may not generate an adequate immune response because secukinumab suppresses the immune system.
Is secukinumab safe to take if I'm pregnant or breastfeeding?
Use of secukinumab during pregnancy has not been evaluated.
Use of secukinumab by nursing mothers has not been evaluated. It is not known whether secukinumab is excreted in human milk.
What else should I know about secukinumab?
What preparations of secukinumab are available?
- Solution for injection: 150 mg in Sensoready Pen or single use prefilled syringe
- Powder for injection: 150 mg single use vial
How should I keep secukinumab stored?
Secukinumab Sensoready pens, prefilled syringes and vials must be refrigerated at 2 C to 8 C (36 F to 46 F). They should not be frozen and should be kept in their original cartons to protect them from light until the time of administration.
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Secukinumab (Cosentyx) is a prescription drug used to treat moderate to severe plaque psoriasis in individuals who are are 18 years of age or older, and are candidates for systemic therapy. Side effects, drug interactions, dosing, storage, and pregnancy and breastfeeding safety information should be reviewed prior to taking this medication.
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Related Disease Conditions
Psoriasis is a long-term skin condition that may cause large plaques of red, raised skin, flakes of dry skin, and skin scales. There are several types of psoriasis, including psoriasis vulgaris, guttate psoriasis, inverse psoriasis, and pustular psoriasis. Symptoms vary depending on the type of psoriasis the patient has. Treatment of psoriasis may include creams, lotions, oral medications, injections and infusions of biologics, and light therapy. There is no cure for psoriasis.
Dry skin (xeroderma) may be caused by external factors, like cold temperatures, low humidity, harsh soaps, and certain medications, or internal factors, such as thyroid disease, diabetes, psoriasis, or Sjogren's syndrome. Symptoms and signs of dry skin include itching and red, cracked or flaky skin. The main treatment for dry skin is frequent, daily lubrication of the skin.
Psoriatic arthritis is a disease that causes skin and joint inflammation. Symptoms and signs include painful, stiff, and swollen joints, tendinitis, and organ inflammation. Treatment involves anti-inflammatory medications and exercise.
Scalp Psoriasis (Psoriasis of the Scalp)
Scalp psoriasis causes red, raised, scaly patches that may extend from the scalp to the forehead and the back of the neck and ears. Symptoms and signs include itching, hair loss, flaking, silvery scales, and red plaques. Treatment includes topical medicated shampoos, creams, gels, oils, ointments, and soaps, medications, and light therapy.
Is Psoriasis Contagious?
Psoriasis is an incurable skin disease that causes reddish patches of skin topped with a thick layer of dry silvery scales. Psoriasis cannot spread and is not contagious.
Non-Radiographic Axial Spondyloarthritis (nr-axSpA)
Non-radiographic spondyloarthritis (nr-axSpA) is an inflammatory arthritis that mainly affects the joints of the spine. Morning stiffness and back pain are the usual symptoms of nr-axSpA. Nonsteroidal anti-inflammatory drugs, exercise, and biologics are treatments for nr-axSpA.
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