What are signs and symptoms of mixed connective tissue disease?
The signs and symptoms of mixed connective tissue disease vary greatly from one individual affected to another. If polymyositis is the dominant feature, muscle weakness is prominent. If systemic lupus erythematosus prevails, there may be chest pain with breathing, kidney disease, and/or arthritis of the joints. If scleroderma symptoms dominate, there can be diffuse swelling and thickening of the fingers and feet with bluish discoloration of the fingers after cold exposure (Raynaud's phenomenon).