What is the treatment for exocrine pancreatic insufficiency (EPI)?
The treatment for exocrine pancreatic insufficiency is termed pancreatic enzyme replacement therapy (PERT). This therapy involves taking prescription drugs that replace the enzyme(s) that your pancreas either produces in insufficient amounts or simply does not produce any enzyme(s). The following six pancreatic enzyme products (PEPs) have been approved by the US FDA to treat maldigestion and/or exocrine pancreatic insufficiency:
- Creon, Zenpep (pancrelipase enteric)
- Pancreaze, Ultrase, Viokace, Pertzye (pancrelipase)
Your doctors can prescribe those drugs that are most likely to benefit you as an individual. In addition to those PEPs listed above, you may require additional medications such as antacids, protein pump inhibitors (PPIs) and possibly some pain medications like Tylenol (acetaminophen).