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What is the treatment for exocrine pancreatic insufficiency (EPI)?

The treatment for exocrine pancreatic insufficiency is termed pancreatic enzyme replacement therapy (PERT). This therapy involves taking prescription drugs that replace the enzyme(s) that your pancreas either produces in insufficient amounts or simply does not produce any enzyme(s). The following six pancreatic enzyme products (PEPs) have been approved by the US FDA to treat maldigestion and/or exocrine pancreatic insufficiency:

  • Creon, Zenpep (pancrelipase enteric)
  • Pancreaze, Ultrase, Viokace, Pertzye (pancrelipase)

Your doctors can prescribe those drugs that are most likely to benefit you as an individual. In addition to those PEPs listed above, you may require additional medications such as antacids, protein pump inhibitors (PPIs) and possibly some pain medications like Tylenol (acetaminophen).

Return to Exocrine Pancreatic Insufficiency (EPI)

See what others are saying

Comment from: kittens, 65-74 Female (Patient) Published: April 19

I have just been diagnosed with exocrine pancreatic insufficiency (EPI) about a month ago. I am on Pertzye and diet with fats, carbs and proteins from specific foods. No supplements have been prescribed as of yet. I am still waiting on blood and 24 hour urine catch results.

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