What is the treatment for histoplasmosis?
Mild cases of histoplasmosis that are limited to the lungs will resolve without specific treatment in about a month. Severe or disseminated cases of histoplasmosis require treatment with antifungal medications. Itraconazole (Sporanox, Onmel), fluconazole (Diflucan), and amphotericin B (Ambisome, Amphotec; drug of choice for severe disease) are antifungal drugs that are typically used to treat histoplasmosis. Treatment may need to be continued for a period of several months.