What medications treat diarrhea (IBS-D) and constipation (IBS-D) in irritable bowel syndrome?
Diarrhea medicine for IBS
- Antidiarrheal medications such as loperamide (Imodium), attapulgite (Kaopectate), and diphenoxylate and atropine (Lomotil) can be helpful if loose stools are one of the main signs. Eluxadoline (Viberzi) is a prescription for the treatment of irritable bowel syndrome with diarrhea (IBS-D).
- For females with IBS who experience severe diarrhea, alosetron (Lotronex) has been used.
- Rifaximin (Xifaxan) is an antibiotic for the treatment of irritable bowel syndrome with diarrhea (IBS-D) and IBS-related bloating.
- Bile acid binders including cholestyramine ( (Prevalite), colestipol (Colestid), or colesevelam (Welchol) can help some patients with IBS-D, but can also cause bloating.
Constipation medication for IBS
- Over-the-counter laxatives such as polyethylene glycol 3350 ( (MiraLAX), bisacodyl (Dulcolax), and psyllium seed husks (Metamucil) can help relieve constipation and keep bowel movements regular. Senna laxatives (Senokot, Ex-Lax Gentle Nature) may be taken short-term. Prescription laxatives such as lactulose (Constulose) may also be prescribed.
- Two drugs specifically used to treat IBS are lubiprostone (Amitiza), a laxative, and linaclotide (Linzess), a constipation medication.
- SSRI antidepressants fluoxetine (Prozac), citalopram (Celexa), sertraline (Zoloft), paroxetine (Paxil), and escitalopram (Lexapro) may be helpful for those with constipation (IBS-C), but they can trigger IBS attacks in patients with diarrhea (IBS-D).