Does the direction of travel matter?
Yes. Travelers flying north or south in the same time zone typically experience the fewest problems because the time of day always remains the same as in the place where the flight originated. These travelers may experience discomfort, but this usually results from confinement in an airplane for a long time or from differences in climate, culture, and diet at the destination location. Time differences do not play a role.
Travelers flying east, on the other hand, typically experience the most problems because they "lose" time. For example, on an international flight from Washington, D.C., to Mecca, Saudi Arabia, a traveler loses eight hours. Meals, sleep, bowel habits, and other daily routines are all pushed ahead eight hours.
Travelers flying west "gain" time and usually have an easier time adjusting than eastward travelers. However, they too experience symptoms of jet lag after landing because they still must adjust to a different schedule.