Medical Definition of Antidepressant, tricyclic

Antidepressant, tricyclic: One of a class of medications used to treat depression. The tricyclic antidepressants (TCAs) are also used for some forms of anxiety, fibromyalgia, and the control of chronic pain.

"Tricyclic" refers to the presence of three rings in the chemical structure of these drugs.

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Last Editorial Review: 7/1/2016

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