Medical Definition of Blood clots, estrogen-associated

  • Medical Author:
    Melissa Conrad Stöppler, MD

    Melissa Conrad Stöppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stöppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology.

Reviewed on 12/27/2018

Blood clots, estrogen-associated: Blood clots are occasional but serious side effects of estrogen therapy. They are dose-related, that is, they occur more frequently with higher doses of estrogen.

Estrogen therapy preparations (all of which carry this risk) include:

The brand names of the estrogen therapy preparations carrying this risk include:

  • CLIMARA (estradiol)
  • ESTRACE (estradiol)
  • ESTRADERM (estradiol)
  • ESTRATAB (esterified estrogens)
  • ESTRATEST (esterified estrogens and methyltestosterone)
  • MENEST (esterified estrogens)
  • OGEN (estropipate)
  • PREMARIN (estrogens conjugated)
  • PREMPHASE (estrogens conjugated and medroxyprogesterone)
  • PREMPRO (estrogens conjugated and medroxyprogesterone)

Cigarette smokers on estrogen therapy are at a higher risk than non-smokers for blood clots. Therefore, patients requiring estrogen therapy are strongly encouraged to quit smoking.

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Reviewed on 12/27/2018