Drug Safety: There's No Magic Pill, Study Says

By Amanda Gardner
HealthDay Reporter

TUESDAY, May 8 (HealthDay News) -- If you think fighting red-hot blazes in collapsing buildings is risky, think again.

Swallowing one aspirin each day for a year poses the same risk of death, new research suggests.

In an analysis appearing in the May/June issue of Health Affairs, researchers compared half a dozen risky drugs to various occupational, recreational and transportation activities, with sometimes surprising results. For instance, few people know that aspirin carries a high risk of gastrointestinal bleeding.

"It's nice to have a rigorous evaluation of not just one drug vs. the other, but some of the more risky pharmaceuticals compared to things that are widely done in day-to-day life," added Dr. A. Mark Fendrick, co-director of the University of Michigan Center for Value Based Insurance Design, and professor at the University of Michigan Medical School and University of Michigan School of Public Health in Ann Arbor. He was not involved in the study.

Drug safety is increasingly a concern of doctors and patients and, thanks to a few high-profile recalls such as Vioxx, has recently made it onto the national legislative agenda.

"There's been a lot of interest in drug safety in the last few years," confirmed study author Joshua Cohen, a research associate professor of medicine at Tufts-New England Medical Center in Boston.

But are people missing something in all the talk of drug safety? Do they fully understand what the risks are when they pop a pill to ward off a supposedly greater ill?

"You can't evaluate the acceptability of a risk without also looking at the benefit of associated activities, because risks are inevitable in all areas of life," Cohen said. "We wanted to see if we could compare risks associated with medication use with other risks that people might be more familiar with."

To that end, Cohen and a colleague evaluated the risk of dying after the use of six drugs: smallpox vaccine; antihistamines for the treatment of allergies for four months out of every year; aspirin for cardiovascular protection; clozapine to treat schizophrenia; Tysabri, a multiple-sclerosis drug; and Vioxx, the now-retired painkiller.

These were then compared to various non-drug activities, with these findings:

  • Taking aspirin carries a risk of death similar to driving a car or working as a firefighter. "Motor vehicle risk I've always known to be a very big risk," Cohen said. "The risk associated with aspirin is just as big."
  • The risk of dying from Vioxx or Tysabri is about the same as dying in a car, working as a truck driver or rock climbing.
  • The odds of dying from aspirin, clozapine, Tysabri and Vioxx are about equal to the corresponding risk for driving in a passenger car.
  • Out of all modes of transportation, only motorcycles pose a greater risk (450 per 100,000 person-years) than all drugs, even Vioxx, which had a 76 per 100,000 person-years fatality rate.
  • Aspirin, clozapine, Tysabri and Vioxx all had risks equal to or greater than the annual mortality risks for firefighters and law enforcement workers (about 11 per 100,000 person-years). The most risky occupation -- tree fallers -- was much higher than any drug, at 360 per 100,000 person-years.
  • Rock climbing (36 deaths per 100,000 person-years) had a mortality rate about equivalent to clozapine, while climbing in the Himalayas (13,000 per 100,000 person-years) had a higher risk of death than any of the drugs studied.
  • And, just as a curiosity, the researchers found that motorcyclists can potentially face annual fatality risks that are 40 times as great as passenger car travelers, while taxi drivers face three times the death risk of firefighters.

"What we found, and this isn't a huge surprise, is that there are a lot of activities that people engage in voluntarily that have associated with them risks comparable to medication risks," Cohen said. "People must be taking into account benefits for those activities."

But perhaps the illustrations highlighted in this paper will help people make those decisions more clear-headedly, he said.

"When it comes to medication, we have to be methodological and cool-headed in looking at risks, not that they should be ignored, but we need to look at them within a framework," Cohen said. "We need a way of thinking about these risks rationally."

Fendrick agreed the new findings can give patients a new perspective on medication risks.

"It's intriguing to think that a person taking aspirin therapy has a reasonable likelihood to prevent a life-ending heart attack but then may then drive off on a motorcycle without a helmet," he said.

SOURCES: Joshua Cohen, Ph.D., research associate professor, medicine, Tufts-New England Medical Center, Boston; A. Mark Fendrick, M.D., co-director, University of Michigan Center for Value Based Insurance Design and professor, U-M Medical School and U-M School of Public Health, Ann Arbor; May/June 2007, Health Affairs

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