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Intensive Treatment of Gum Disease May Yield Healthier Blood Vessels
By Miranda Hitti
WebMD Health News
Reviewed By Louise Chang, MD
on Wednesday, February 28, 2007
Feb. 28, 2007 -- In people with gum disease , intensive treatment may benefit blood vessels as well as their gums.
This study, published in The New England Journal of Medicine, comes from the University of Connecticut's Maurizio Tonetti, DMD, PhD, along with colleagues in London.
About the Study
Nearly a third were current smokers, and 30% were former smokers.
A healthy endothelium means better endothelial dilation, which means better blood flow. Poor endothelial function may be an early warning sign of heart disease, note the researchers.
Next, patients were randomly split into two groups.
One group got standard gum disease treatment -- having a dentist scrape and polish their teeth.
Lastly, the patients provided more blood samples and repeated the endothelial function tests periodically for six months following treatment.
One day after gum disease treatment, patients in the intensive treatment group had higher levels of inflammatory chemicals in their blood and worse endothelial function than those who received standard care.
But two months later, the intensive treatment group had better endothelial function than the standard treatment group. That advantage was still seen at the end of the six-month study.
Intensive treatment of gum disease may briefly boost inflammation and curb endothelial function, but it appears to be better for the endothelium in the long run, the researchers say.
"Six months after therapy, the benefits in oral health were associated with improvement in endothelial function," they write.
It's not clear if the findings apply to people with less severe gum disease or those with other heart health risk factors.
SOURCE: Tonetti, M. The New England Journal of Medicine, March 1, 2007; vol 356: pp 911-920.
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