Medical Definition of Kimmelstiel-Wilson disease

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Kimmelstiel-Wilson disease: Diabetic kidney disease affects about one half of patients with long-standing diabetes. It affects the glomerulus, a key structure in the kidney that is composed of capillary vessels necessary for the filtration of the blood. A cardinal feature is the excessive filtration of albumin into the urine (albuminuria). Patients may also have high blood pressure (hypertension). When severe, Kimmelstiel-Wilson disease leads to kidney failure, end-stage renal disease, and the need for chronic kidney dialysis or a kidney transplant.

Diabetic kidney disease affects about one half of patients with long-standing diabetes. Screening for this condition is advised for all patients with both type 1 and type 2 diabetes mellitus.

The disorder is named for Paul Kimmelstein, a pathologist and Clifford Wilson, an English physician. It is also known as Kimmelstiel-Wilson syndrome or intercapillary glomerulonephritis.

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Reviewed on 12/27/2018

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