Medical Definition of Granulomatosis with polyangiitis

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Granulomatosis with Polyangiitis: An uncommon type of inflammation of small arteries and veins (vasculitis) that classically involves the vessels supplying the tissues of the lungs, nasal passages (sinuses), and kidneys.

Granulomatosis with polyangiitis usually affects young or middle-aged adults.

Symptoms include fatigue, weight loss, fever, shortness of breath, bloody sputum, joint pains, and sinus inflammation, sometimes with nasal ulcerations and bloody nasal discharge.

The diagnosis of granulomatosis with polyangiitis is confirmed by finding evidence of vasculitis and abnormal cellular formations called granulomas on biopsy of tissue involved by the inflammatory process.

Granulomatosis with polyangiitis is a serious disease. Without treatment, it can be fatal within months. Treatment is directed toward stopping the inflammation process by suppressing the immune system.

Reviewed on 7/11/2018

REFERENCE: Tracy, CL, MD, et al. Granulomatosis with Polyangiitis (Wegener Granulomatosis). Medscape. Updated: Dec 02, 2017.
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