Medical Definition of Primary biliary cirrhosis (PBC)

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Primary biliary cirrhosis (PBC): A liver disease caused by an abnormality of the immune system. Small bile ducts within the liver become inflamed and obliterated. Backup of bile causes intense skin itching and yellowing of the skin (jaundice). Lack of bile decreases absorption of calcium and vitamin D, leading to osteoporosis. Cirrhosis (scarring of the liver) develops over time.

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Reviewed on 12/27/2018

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