Medical Definition of p53

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

P53: A specific protein with a mass of 53 kilodaltons that is produced by a tumor-suppressor gene. Like other tumor-suppressor genes, the p53 gene normally controls cell growth. If p53 is physically lost or functionally inactivated, cells can grow without restraint. Many human tumors have mutations in the gene coding for the p53 protein.

Reviewed on 12/12/2018

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