Weight Loss:
Very Low-Calorie Diets

Last Editorial Review: 7/12/2005
The Cleveland Clinic

Traditional weight loss methods include low-calorie diets that allow between 800 to 1,500 calories a day and encourage regular exercise. However, an alternative method that moderately to severely obese people may consider for significant, short-term weight loss is the very low-calorie diet (VLCD).

Many VLCDs are commercially prepared formulas of 800 calories or less that replace all usual food intake. Others, such as the well-known grapefruit diet (also called the Hollywood Diet), rely on eating a lot of the same low-calorie food or foods. VLCDs are not the same as over-the-counter meal replacements, which are substituted for one or two meals a day.

How Effective Are VLCDs?

A VLCD may allow a severely to moderately obese person to lose about 3 to 5 pounds per week, for an average total weight loss of 44 pounds over 12 weeks. Such a weight loss can improve obesity-related medical conditions , including diabetes, high blood pressure and high cholesterol. However, VLCDs are no more effective than more modest dietary restrictions in the long-term maintenance of reduced weight. Combining a VLCD with behavioral therapy and exercise may increase weight loss and help keep it off for the long-term. Behavioral therapy helps you to recognize what causes you to overeat so that you can consciously change those behaviors.

Are VLCDs Safe?

VLCDs are generally safe when used under proper medical supervision in people with a body mass index (BMI) greater than 30. Use of VLCDs in people with a BMI of 27 to 30 should be reserved for those who have medical complications resulting from their obesity.

VLCDs are not suitable for everyone. Doctors generally recommend them on a case-by-case basis and your doctor will decide whether or not such a diet is appropriate for you. VLCDs are not recommended for pregnant or breastfeeding women, and are not appropriate for children or adolescents except in specialized treatment programs. Due to the need for other medications for preexisting conditions, as well as the possibility of side effects, these types of diets may not be suitable for people over 50, either.

What Are the Side Effects to VLCDs?

Many people on a VLCD for 4-16 weeks report minor side effects such as fatigue, constipation, nausea and diarrhea, but these conditions usually improve within a few weeks and rarely prevent people from completing the program.

The most common serious side effect seen with VLCDs is gallstone formation. Gallstones, which frequently develop in obese people (especially women), are even more common during rapid weight loss. The reason for this may be that rapid weight loss appears to decrease the gallbladder's ability to contract bile. But, it is unclear whether VLCDs directly cause gallstones or whether the amount of weight loss is responsible for the formation of gallstones.

What Are the Other Drawbacks?

To be healthy, we need a balance of foods from different food groups. It's quite difficult to get good nutrition in as few as 800 calories (a dietitian would have trouble doing this), especially if one eats the same foods day after day.

Also, once you go off the diet, you will likely regain your weight unless you change your lifestyle and commit to healthy eating , regular physical activity and an improved outlook about food. By sticking to a long-term commitment, you can prevent your weight from drifting back up the scale.

Reviewed by the Department of Nutrition Therapy at The Cleveland Clinic.

Edited by Charlotte Grayson, MD, WebMD, August 2004.

Portions of this page © The Cleveland Clinic 2000-2004


According to the USDA, there is no difference between a “portion” and a “serving.” See Answer

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