Medical Definition of In situ hybridization

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

In situ hybridization: The use of a DNA or RNA probe to detect complementary genetic material in cells or tissue. In situ hybridization involves hybridizing a labeled nucleic acid to suitably prepared cells or tissues on microscope slides to allow visualization in situ (in the normal location).

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Reviewed on 12/12/2018

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