Medical Definition of Histamine

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Histamine: A substance that plays a major role in many allergic reactions, dilating blood vessels and making the vessel walls abnormally permeable. Histamine is part of the body's natural allergic response to substances such as pollens. Antihistamines work by preventing the release of histamine from certain cells (mast cells) thereby blocking the allergic reaction.

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Reviewed on 12/12/2018

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