Medical Definition of Hemophilia A

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Hemophilia A: Classic hemophilia, which is due to a profound deficiency in the activity of clotting factor VIII. Affected individuals suffer hemorrhage into joints and muscles, easy bruising, and prolonged bleeding from wounds. The disease is inherited as an X-linked trait, so males are affected and females carry the gene. Treatment involves administration of blood products that introduce clotting factor VIII and replace lost blood. Use of contaminated blood products exposed many people with hemophilia to HIV infection in the 1980s and 1990s. Hemophilia A has affected the Russian royal house and the descendants of Queen Victoria.

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Reviewed on 12/12/2018

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