Medical Definition of PLP1

PLP1: The gene encoding proteolipid protein, or lipophilin, the primary constituent of myelin. The PLP1 gene is on the X chromosome in band Xq22. Mutations in PLP1 cause Pelizaeus-Merzbacher disease (PMD) and X-linked spastic paraplegia 2 (SPG2).

Last Editorial Review: 9/14/2016

Health Solutions From Our Sponsors

Health Solutions From Our Sponsors