Medical Definition of Familial eosinophilia

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Familial eosinophilia: An autosomal dominant condition characterized by an abnormally high level of eosinophils in the blood. Despite the prolonged eosinophilia, there may be no symptoms. The gene for familial eosinophilia, called EOS, has been mapped to chromosome region 5q31-33 containing the cytokine gene cluster which includes the genes for interleukin-3 (IL-3), interleukin-5 (IL-5), and granulocyte colony-stimulating factor (G-CSF), and all of which are thought play roles in the development, proliferation, and activation of eosinophils.

CONTINUE SCROLLING OR CLICK HERE FOR RELATED ARTICLE
Reviewed on 9/7/2018

Health Solutions From Our Sponsors