Medical Definition of Leucovorin

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Leucovorin: Folinic acid, the active form of folic acid in the body. Used as an antidote to protect normal cells from high doses of the anticancer drug methotrexate and to increase the antitumor effects of fluorouracil (5-FU) and tegafur-uracil. Also used to prevent or treat anemia due to folic acid deficiency. Also known as citrovorum factor and Wellcovorin.

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Reviewed on 10/30/2018

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