Medical Definition of Thromboxane

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Thromboxane: A substance made by platelets that causes blood clotting and constriction of blood vessels. It also encourages platelet aggregation. There are two thromboxanes. Thromboxane A2 (TXA2) is active but is very unstable and has a half-life of only 30 seconds before it undergoes hydrolysis to form thromboxane B2 (TXB2) which is inactive. The thromboxanes are derived from arachidonic acid and are related to prostaglandins. Aspirin acts by inhibiting the COX enzyme from synthesizing precursors of thromboxane in platelets thereby reducing platelet aggregation.

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Reviewed on 12/21/2018

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