Medical Definition of EGF

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

EGF: Epidermal growth factor. A polypeptide (small protein) that is a powerful mitogen. (It stimulates cells to enter mitosis, cell division. ) EGF promotes cell growth and differentiation, is essential in embryogenesis, and is important in wound healing. It is produced by many normal cell types and is made in large amounts by some tumors. The EGF gene is on chromosome 4q25 (whereas the gene for its receptor, EGFR, is on chromosome 7). The kidney is the main source of circulating EGF. EGF is also known as urogastrone (URG).

Reviewed on 12/21/2018

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