Medical Definition of Glutathione S-transferase

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Glutathione S-transferase: A family of enzymes that utilize glutathione in reactions contributing to the transformation of a wide range of compounds, including carcinogens, therapeutic drugs, and products of oxidative stress.

The glutathione S-transferases act by catalyzing the reaction of glutathione with an acceptor molecule to form an S-substituted glutathione (S = sulfur). See also: Glutathione S-transferase omega-1.

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Reviewed on 12/21/2018

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