Medical Definition of Glutathione S-transferase omega-1

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Glutathione S-transferase omega-1: An enzyme that remarkably influences the age of onset of symptoms of two common degenerative brain disorders -- both Alzheimer disease and Parkinson disease.

Glutathione S-transferase omega-1 (GSTO1) belongs to a family of enzymes that utilize glutathione in reactions contributing to the transformation of a wide range of compounds, including carcinogens, therapeutic drugs, and products of oxidative stress. The gene encoding GSTO1 is on chromosome 10. Also written: Glutathione S-transferase, omega-1.

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Reviewed on 12/21/2018

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