Liver biopsy: A procedure in which a small sample of the liver is removed for the diagnosis of abnormal liver conditions. The most common method for obtaining a liver biopsy is percutaneous ('through the skin'). A percutaneous biopsy involves insertion of a biopsy needle through the skin and chest wall over the lower right side of the chest (directly over the liver) using a local anesthetic.
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Last Editorial Review: 6/9/2016