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The U.S. Food and Drug Administration on Tuesday warned health care workers to look out for patients who may have been exposed to a potentially deadly animal sedative, possibly through illicit drug use.
The non-opioid -- sometimes called tranq -- is approved for use in animals as a sedative and pain reliever. It is not safe for use in humans.
Deaths tied to xylazine have increased significantly in recent years. According to the U.S. National Institute on Drug Abuse, overdose deaths involving xylazine jumped from 2% to 26% in Pennsylvania alone between 2015 and 2020.
Serious side effects may resemble those linked to opioid use, making it difficult to distinguish opioid overdoses from xylazine exposure. Moreover, naloxone, which can reverse the effects of some opioid drug overdoses, may not have the same effect on xylazine, the agency said.
The FDA warned health care professionals not to administer reversal agents used for xylazine in veterinary medicine because it is not known whether they are safe or effective in humans.
The FDA advised health care professionals to continue administering naloxone when they suspect someone is experiencing an opioid overdose. And providers should consider xylazine exposure if the patient does not respond to naloxone.
Other symptoms of xylazine exposure include slowed breathing and severe, necrotic skin ulcerations.
Complicating the issue, routine toxicology screens do not detect xylazine.
Health care professionals and patients should report exposure to xylazine to the FDA's MedWatch Adverse Event Reporting program at www.fda.gov/medwatch/report.htm. You can also download and fax the completed form to 1-800-FDA-0178.
The U.S. National Institute on Drug Abuse has more on xylazine.
SOURCE: U.S. Food and Drug Administration, news release, Nov. 8, 2022
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