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A small study of 133 fully vaccinated people taking immunosuppressive medications found that their antibody levels and ability to neutralize the virus were three times lower than in people not taking these medications.
However, “most patients in the study were able to mount antibody responses in response to SARS-CoV-2 vaccination, which is reassuring," study co-author Dr. Alfred Kim, an assistant professor of rheumatology at Washington University School of Medicine in St Louis, told Reuters.
The study was published on the preprint server MedRxiv, and has not been peer-reviewed.
“Not all medications that our patients take have been shown to have significant effects on responses to vaccination," said Dr. David Karp, president of the American College of Rheumatology, who suggested patients ask their health care provider if they are likely to see benefits from additional vaccination.
Karp added that it's still unclear how much protection a third or fourth booster provides to immunocompromised patients, such as those with cancer, organ transplants and those taking immunosuppressive medications.
So, even if these patients do receive additional COVID vaccine doses, they should continue to take precautions such as physical distancing and wearing masks, Karp advised.
The U.S. Centers for Disease Control and Prevention advises immunocompromised patients who received an mRNA vaccine to seek third doses at least four weeks after their second shot. If possible, the booster should match their previous shots.
In other words, those who received two doses of the Pfizer-BioNTech vaccine should stick to that for their third shot. Those who initially received the Moderna vaccine should get a Moderna booster.
Immunocompromised patients who received the Johnson & Johnson vaccine should receive a second shot at least two months after their first dose. They can get a second J&J shot or an mRNA vaccine, the CDC says.
The Arthritis Foundation noted that there is some evidence that an mRNA booster may improve immunity in those who first received the J&J vaccine.
The U.S. Centers for Disease Control and Prevention has more on COVID-19 vaccines for people with underlying medical conditions.
SOURCE: Arthritis Foundation, news release, Jan. 3, 2022
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