Medical Definition of Plague bacterium genome

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Plague bacterium genome: All of the DNA (the genome) of the bacterium Yersinia pestis that causes the plague, consisting of four rings of DNA -- a large circular chromosome made up of 4,653,728 bases of DNA and three much smaller rings, or plasmids -- and including about 150 genes made inactive by mutation, a process that affects genes the organism no longer needs. Since some of these inactive genes are known in other bacteria to be involved in colonizing the intestinal tract, it has been inferred that the plague bacterium's ancestor once lived in the gut and then acquired genes from other bacteria that let it move from the gut to the blood, and also conferred upon it the ability to colonize fleas. Thus armed, the bacterium morphed from a minor cause of gastroenteritis to a major scourge.

The sequencing of the plague genome was carried out at the Sanger Centre in England and completed in 2001.

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Reviewed on 12/21/2018

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