Medical Definition of Placental growth factor

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Placental growth factor: A type of vascular endothelial growth factor. Placental growth factor is expressed not only in placental cells but also many nonplacental cells including endothelial cells (that line blood vessels). The gene that encodes placental growth factor is in chromosome region 14q24-q31.

Placental growth factor is a molecular marker for inflammation. In patients with acute chest pain, a high blood level of placental growth factor predicts a poor prognosis (outlook).

Abbreviated as PIGF, PGF, or PLGF.

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Reviewed on 10/30/2018

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