Medical Definition of Annotation

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Reviewed on 9/7/2018

Annotation: In genetics, the process of identifying the locations and coding regions of genes in a genome and determining what those genes do. To annotate (irrespective of the context) is to add a note by way of explanation or commentary. Once a genome is sequenced, it needs to be annotated to make sense of it.

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Reviewed on 9/7/2018