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Statins are widely prescribed to people with heart disease, and recent guidelines recommend greater preventive use of the drugs even before heart issues are diagnosed. But it hasn't been clear whether the benefits outweigh the risks in people without heart disease.
To find out, researchers analyzed data from 62 trials with more than 120,000 people (average age: 61), who were followed for an average of 3.9 years.
Statins were linked with a slightly higher risk of self-reported side effects such as muscle pain, liver and kidney problems, and eye conditions such as cataracts. But they were not associated with clinically confirmed muscle disorders or diabetes.
But the reduced risk of major heart events provided by statin use outweighed the potential side effects, according to the study. The drugs were estimated to prevent 19 heart attacks, nine strokes and eight deaths from heart disease for every 10,000 patients treated for a year.
The findings suggest a favorable benefit-to-harm balance for primary prevention of heart disease, according to the team led by James Sheppard, of the Nuffield Department of Primary Care Health Sciences at the University of Oxford in the U.K.
The low risk of harm posed by statins "should reassure patients and physicians that the potential harms of statins are small and should not deter their use for primary prevention of cardiovascular disease," they wrote.
They said further studies are needed to improve patients' adherence to treatment and make monitoring more efficient.
There's more on statins at the U.S. National Library of Medicine.
SOURCE: BMJ, news release, July 14, 2021
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