Medical Definition of Interleukin-10

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Interleukin-10: Abbreviated IL-10. An antiinflammatory and immunosuppressive substance produced within the body. IL-10 plays a role in the regulation of immune responses. It is secreted by antigen-presenting cells, promotes the development of immunologic tolerance, and suppresses the production of inflammatory cytokines. The gene for IL-10 is in chromosome region 1q31-q32.

IL-10 modulates acute graft-versus-host disease (GVHD), a major complication in bone marrow transplant. The presence of a particular variant in the recipient's IL-10 gene is associated with a substantial decrease in the risk of GVHD. Knowledge of the recipient's IL-10 genotype helps predict the chance of GVHD.

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Reviewed on 10/30/2018

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