MEF2A

What Kind of Doctor Do I Need? Slideshow

Medical Definition of MEF2A

MEF2A: A transcription factor that participates in vascular development. MEF2A is a member of the myocyte enhancer factor-2 (MEF2) family of transcription factors. Messenger RNA (mRNA) from MEF2A has been detected in blood vessels during early embryogenesis. The gene for MEF2A is located on chromosome 15q26.

A heritable deletion within the MEF2A gene that results in the loss of 7 amino acids appears responsible for an autosomal dominant form of coronary artery disease. The deletion alters the cellular distribution of the MEF2A protein and may prevent its function as a vascular transcription factor. It remains to be seen if the MEF2A pathway plays a role in the common form of coronary artery disease resulting from atherosclerosis.

MEF2A is also known as MADS box transcription enhancer factor 2, polypeptide A.


Subscribe to MedicineNet's General Health Newsletter

By clicking Submit, I agree to the MedicineNet's Terms & Conditions & Privacy Policy and understand that I may opt out of MedicineNet's subscriptions at any time.

Reviewed on 9/14/2016

Health Solutions From Our Sponsors