Medical Definition of PYY

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

PYY: A hormone concerned with hunger and the lack of hunger (satiety). Soon after eating, PYY is secreted into the blood by cells lining the lower small intestine (the ileum) and the colon. The release of PYY begins before nutrients arrive in the lower small intestine and the colon. The further release of PYY is stimulated by nutrients within the lower small intestine and the colon. PYY decreases food intake by inhibiting gut motility. It acts as an "ileal brake" to cause a sense of satiety. PYY is a peptide.

Reviewed on 12/11/2018

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