Medical Definition of BASE breast cancer gene

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Reviewed on 12/11/2018

BASE breast cancer gene: A breast cancer gene first reported in 2003 that encodes a protein secreted only by breast cancer and salivary gland cells. Hence the name, BASE (Breast cancer And Salivary gland Expression). The normal breast makes very little, if any, of the BASE protein whereas certain kinds of breast cancers produce quite a lot of it. Determining the levels of BASE in the blood may be of use in screening for breast cancer and for following a patient's progress on breast cancer treatment.

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Reviewed on 12/11/2018