Medical Definition of Paraoxonase

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Paraoxonase: An enzyme associated with high-density lipoprotein (HDL) that is believed to protect against the oxidation of low-density lipoprotein (LDL) and hence to affect the risk of coronary artery disease. There are 3 paraoxonase genes (PON1, PON2 and PON3) all of which are clustered in the same region on chromosome 7. The severity of coronary artery disease, in terms of the number of diseased vessels, is affected by common genetic variations in the PON gene cluster.

CONTINUE SCROLLING OR CLICK HERE FOR RELATED ARTICLE
Reviewed on 10/30/2018

Health Solutions From Our Sponsors