Medical Definition of Kinome

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Kinome: A subset of the genome consisting of the protein kinase genes. The complete complement of over 500 protein kinases constitutes one of the largest of all human gene families. Protein kinases act as key regulators of cell function by catalyzing (facilitating) the addition of a negatively charged phosphate group to proteins. This process of protein phosphorylation, in turn, regulates protein function in both normal and disease states.

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Reviewed on 12/11/2018

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