Medical Definition of Peroxisome proliferator-activated receptor (PPAR)

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

Peroxisome proliferator-activated receptor (PPAR): a type of nuclear hormone receptor within cells that ultimately affects gene expression. There are 3 types of PPARs: alpha, gamma, and beta/delta. These receptors play a major role in the maintenance of metabolism, cell differentiation, and inflammation.

Reviewed on 1/3/2019

REFERENCE: Tyagi et al. The peroxisome proliferator-activated receptor: A family of nuclear receptors role in various diseases. J Adv Pharm Technol Res. 2011 Oct-Dec; 2(4): 236–240.

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