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In Kentucky, health officials say 400 cases have been identified since August and a statewide outbreak was declared in November. Since November, 76 cases have been identified in Indiana, according to health officials, CNN reported.
Both states have an average of about 20 hepatitis cases a year.
Michigan, Utah, Colorado and California have had increases in hepatitis A cases over the past year.
The hepatitis A virus is found in the feces of infected people and is most frequently transmitted by eating food or drinking water handled by someone with the virus who has not properly washed their hands. The virus is also transmitted by sex and by illicit drug use, CNN reported.
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