Medical Definition of GM1 gangliosidosis

  • Medical Author:
    William C. Shiel Jr., MD, FACP, FACR

    Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.

GM1 gangliosidosis: A genetic lipid storage disorder that is similar in certain respects to Hurler syndrome and Tay-Sachs disease but which affects both the brain and the viscera (the internal organs). GM1 gangliosidosis causes skeletal deformities and exerts severe effects on the brain and internal organs. Death usually occurs by the age of 2.

GM1 gangliosidosis is one of the classic lipid storage diseases. The gene responsible for it maps to chromosome 3. There is no treatment for the disease. It is also known as familial neurovisceral lipidosis and Landing disease (after the pioneering pediatric pathologist Ben Landing).

See also Hurler syndrome and Tay-Sachs disease.

Reviewed on 9/7/2018

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