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The researchers, who used Danish and Swedish hospital data to track the incidence of 44 different illnesses over 10 years, found no "serious safety concerns" for women who'd gotten the HPV vaccine to reduce their odds for cervical cancer.
The study did find slightly higher odds for celiac disease among vaccinated women, but this was seen only in Denmark. The authors noted that celiac disease is "markedly underdiagnosed" in the Danish population, so that could account for that finding. Celiac disease is an autoimmune disease that is triggered by eating gluten, a protein found in wheat and grain products.
Because HPV is sexually transmitted, the U.S. Centers for Disease Control and Prevention recommends vaccination before the start of sexual activity. Ideally, that is between the ages of 9 and 12.
Two U.S. obstetrician/gynecologists agreed.
"Since the vaccine is typically given to young girls to try to protect them before they are sexually active, few studies have explored the side effects and risks of the vaccine in women that are more mature," said Dr. Benjamin Schwartz, chair of obstetrics and gynecology at Southside Hospital, in Bay Shore, N.Y.
"This is a very important strength of the study, because it further explores the safety of the vaccine in adults," he said.
Schwartz stressed, however, that because of a minority of vaccine skeptics in the United States, actual rates of use of the HPV vaccine are still "quite disappointing." But the new findings "further demonstrate the lack of evidence of adverse risks of the HPV vaccine," he said.
Dr. Mitchell Kramer is chair of obstetrics and gynecology at Huntington Hospital in Huntington, N.Y. He agreed that the study shows "no connections between the administration of the HPV vaccine among adult women and the development of serious, chronic disease." He added that "the celiac issue described in the article is insignificant."
Prevention of HPV-linked cancers is "a tremendously important public health issue, and hopefully [this study] will encourage more women to get vaccinated against HPV," Kramer said.
The study was published Oct. 18 in the Journal of Internal Medicine.
-- E.J. Mundell
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SOURCES: Benjamin Schwartz, M.D., chairman, department of obstetrics and gynecology, Southside Hospital, Bay Shore, N.Y.; Mitchell Kramer, M.D., chairman, obstetrics and gynecology, Huntington Hospital, Huntington, N.Y.; Oct. 18, 2017, Journal of Internal Medicine